The cholera toxin from Vibrio cholerae (CT) and the 80% homologous heat-labile toxin of Escherichia coli (LT) are two well-known cases of sugar-binding proteins. The GM1:toxin complexes were chosen as test cases for the elaboration of a computational approach to the modeling of protein-saccharide interactions. The reliability of the method was evaluated on the LT:lactose complex. A model of this complex was built by performing a MC/EM conformational search of the sugar moiety within the binding pocket of LT, using the AMBER force field and the GB/SA solvation model. The results are a reasonable reproduction of the reported X-ray structure of the complex. The same protocol was then applied to the LT:GM1 complex. The calculations were perform...
Protein-carbohydrate interactions, essential in many biomolecular recognition events, are investigat...
The complex of cholera toxin and ganglioside GM1 is one of the highest affinity protein-carbohydrate...
RECOGNITION of the oligosaccharide portion of ganglioside G(M1) in membranes of target cells by the ...
The cholera toxin from Vibrio cholerae (CT) and the 80% homologous heat- labile toxin of Escherichia...
The oligosaccharide of ganglioside GM1 [Gal beta1-3GalNAc beta1-4(NeuAc alpha2-3)Gal beta1-4Glc beta...
The oligosaccharide of ganglioside GM1 [Gal beta1-3GalNAc beta1-4(NeuAc alpha2-3)Gal beta1-4Glc bet...
Interactions of cholera toxin (CT) with membrane are associated with the massive secretory diarrhea ...
A molecular dynamics (MD) simulation study of the enzymatic portion of cholera toxin; cholera toxin ...
AbstractBackground: Escherichia coli heat-labile enterotoxin (LT) is the causative agent of travelle...
The galactose-binding site in cholera toxin and the closely related heat-labile enterotoxin (LT) fro...
The paper describes the pseudosugar 2 [Galβ1-3GalNAcβ1-4(NeuAcα2- 3)DCCHD], a high affinity binder o...
<div><p>The conformational property of oligosaccharide GT1B in aqueous environment was studied by mo...
The goal of this project was to clarify the mechanism of action of Clostridium tetani toxin through...
The subject of this work is the structural and functional study of protein-carbohydrate complexes. T...
The paper describes the pseudosugar 2 [Gal beta 1-3GalNAc beta 1-4(NeuAc alpha 2-3)DCCHD], a high af...
Protein-carbohydrate interactions, essential in many biomolecular recognition events, are investigat...
The complex of cholera toxin and ganglioside GM1 is one of the highest affinity protein-carbohydrate...
RECOGNITION of the oligosaccharide portion of ganglioside G(M1) in membranes of target cells by the ...
The cholera toxin from Vibrio cholerae (CT) and the 80% homologous heat- labile toxin of Escherichia...
The oligosaccharide of ganglioside GM1 [Gal beta1-3GalNAc beta1-4(NeuAc alpha2-3)Gal beta1-4Glc beta...
The oligosaccharide of ganglioside GM1 [Gal beta1-3GalNAc beta1-4(NeuAc alpha2-3)Gal beta1-4Glc bet...
Interactions of cholera toxin (CT) with membrane are associated with the massive secretory diarrhea ...
A molecular dynamics (MD) simulation study of the enzymatic portion of cholera toxin; cholera toxin ...
AbstractBackground: Escherichia coli heat-labile enterotoxin (LT) is the causative agent of travelle...
The galactose-binding site in cholera toxin and the closely related heat-labile enterotoxin (LT) fro...
The paper describes the pseudosugar 2 [Galβ1-3GalNAcβ1-4(NeuAcα2- 3)DCCHD], a high affinity binder o...
<div><p>The conformational property of oligosaccharide GT1B in aqueous environment was studied by mo...
The goal of this project was to clarify the mechanism of action of Clostridium tetani toxin through...
The subject of this work is the structural and functional study of protein-carbohydrate complexes. T...
The paper describes the pseudosugar 2 [Gal beta 1-3GalNAc beta 1-4(NeuAc alpha 2-3)DCCHD], a high af...
Protein-carbohydrate interactions, essential in many biomolecular recognition events, are investigat...
The complex of cholera toxin and ganglioside GM1 is one of the highest affinity protein-carbohydrate...
RECOGNITION of the oligosaccharide portion of ganglioside G(M1) in membranes of target cells by the ...