The stereoselective synthesis of two precursors of tricyclic beta-lactam antibiotics (trinems) has been attempted by a novel approach that involves a highly stereoselective azetidinone ring-forming reaction followed by the reduction of a functionalized aromatic substituent at C-4 of the beta-lactam nucleus
(3R,4R)-4-Acetoxy-3-[(1'R-tert-butyldimethylsilyloxy)ethyl]-2-azetidinone, one of the best synt...
beta-lactam antibiotics are a mainstay of antimicrobical therapy and play an important role treating...
Department of Chemistry and Chemical Engineering, Stevens Institute of Technology, Hoboken, New Jers...
Two novel approaches to key intermediates for carbapenem synthesis were investigated. The first empl...
A five-step synthesis of novel tricyclic beta-lactams has been exploited by stereoselective intramol...
TiCl4 mediated addition of silyl ketene acetals derived from N-methylephedrine esters to various ald...
The tricyclic beta-lactam 5 has been synthesized both in racemic and enantiopure form starting from ...
Conrotatory ring closure of 1-halo-3-aza-4-alkyl-1,3-dienes in refluxing toluene gives rise to 3-hal...
The C4 benzoyloxy substituted β-lactams (65)-(68) were formed by the copper-promoted reaction of β-l...
A novel and efficient synthetic method for preparing in high stereoselectivity beta-lactams poly-fun...
Starting from the Staudinger [2+2] cycloaddition between the 1-azadiene 1 and acetoxyacetylketene, g...
An efficient synthesis of a beta-lactam precursor of the serine protease, prostate-specific antigen ...
The reaction of the titanium enolalc of a 2-pyridylthioesler derived from (R)-3-hydroxybutync acid w...
none4Beta-Lactam compounds are really “evergreen” molecules. Beside bicyclic beta-lactam substrates ...
cis-4-(1-Chloro-1-methylethyl)-1-(omega-hydroxyalkyl)azetidin-2-ones were diastereoselectively trans...
(3R,4R)-4-Acetoxy-3-[(1'R-tert-butyldimethylsilyloxy)ethyl]-2-azetidinone, one of the best synt...
beta-lactam antibiotics are a mainstay of antimicrobical therapy and play an important role treating...
Department of Chemistry and Chemical Engineering, Stevens Institute of Technology, Hoboken, New Jers...
Two novel approaches to key intermediates for carbapenem synthesis were investigated. The first empl...
A five-step synthesis of novel tricyclic beta-lactams has been exploited by stereoselective intramol...
TiCl4 mediated addition of silyl ketene acetals derived from N-methylephedrine esters to various ald...
The tricyclic beta-lactam 5 has been synthesized both in racemic and enantiopure form starting from ...
Conrotatory ring closure of 1-halo-3-aza-4-alkyl-1,3-dienes in refluxing toluene gives rise to 3-hal...
The C4 benzoyloxy substituted β-lactams (65)-(68) were formed by the copper-promoted reaction of β-l...
A novel and efficient synthetic method for preparing in high stereoselectivity beta-lactams poly-fun...
Starting from the Staudinger [2+2] cycloaddition between the 1-azadiene 1 and acetoxyacetylketene, g...
An efficient synthesis of a beta-lactam precursor of the serine protease, prostate-specific antigen ...
The reaction of the titanium enolalc of a 2-pyridylthioesler derived from (R)-3-hydroxybutync acid w...
none4Beta-Lactam compounds are really “evergreen” molecules. Beside bicyclic beta-lactam substrates ...
cis-4-(1-Chloro-1-methylethyl)-1-(omega-hydroxyalkyl)azetidin-2-ones were diastereoselectively trans...
(3R,4R)-4-Acetoxy-3-[(1'R-tert-butyldimethylsilyloxy)ethyl]-2-azetidinone, one of the best synt...
beta-lactam antibiotics are a mainstay of antimicrobical therapy and play an important role treating...
Department of Chemistry and Chemical Engineering, Stevens Institute of Technology, Hoboken, New Jers...
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