Purpose: To develop an oral multi-particulate drug delivery system (DDS) containing a high dose (i.e.> 1,000 mg) of 5-aminosalicylic acid (5-ASA, mesalamine) for the treatment of Inflammatory Bowel Disease (IBD). Gastric protection, followed by a prolonged and pH-independent release of 5-ASA were sought, aiming to potentially meet the IBD therapeutic needs. Methods: Highly-loaded (95 wt%) 5-ASA pellets were prepared by extrusion-spheronisation (Nica\uae System, model E140) and characterised in terms of size distribution, shape, bulk density and mechanical resistance. Pellets of the selected 710-1,000 \uf06dm size fraction were coated (Glatt\uae GPCG-1) with increasing amounts of a polyvinyl acetate (Kollicoat\uae SR) dispersion to achieve ...
Objective: This study was intended to investigate the potential of the colon specificity approach co...
The small intestine is where most conventional oral formulations are mostly absorbed. This restricts...
Mesalazine (5-ASA) is an anti-inflammatory drug used for ulcerative colitis or Crohn's desease. Most...
Purpose: To develop an oral multi-particulate drug delivery system (DDS) containing a high dose (i.e...
Background: 5-aminosalicylic acid (5-ASA, mesalamine) is at present the treatment of choice for Infl...
Purpose. 5-aminosalicylic acid (5-ASA) has demonstrated its potential to treat IBD (Inflammatory Bow...
5-Aminosalicylate (5-ASA; mesalamine) is the current first-line treatment for mild to moderate ulcer...
Objective: The aim of the present work was to develop new solid pharmaceutical delivery systems of m...
Introduction Recent studies prove that the number of patients with inflammatory bowel disease is inc...
Mesalazine (5-ASA) is the standard drug for the treatment of inflammatory bowel disease (IBD) due to...
Mesalazine (5-ASA) is a compound being used in the therapy of inflammatory bowel disease (IBD). Cons...
Aims: An oral multiparticulate coated formulation of 5‐aminosalicylic acid (5‐ASA; mesalazine) has b...
INTRODUCTION AND OBJECTIVES Mesalazine or 5-aminosalicylic (5-ASA), a typical antiinflatmmatory dru...
Mesalamine is a gold standard anti-inflammatory drug used to treat inflammatory bowel illnesses. It'...
Background: Multi-matrix (MMx), a new delivery system for mesalazine. seems to release 5-aminosalicy...
Objective: This study was intended to investigate the potential of the colon specificity approach co...
The small intestine is where most conventional oral formulations are mostly absorbed. This restricts...
Mesalazine (5-ASA) is an anti-inflammatory drug used for ulcerative colitis or Crohn's desease. Most...
Purpose: To develop an oral multi-particulate drug delivery system (DDS) containing a high dose (i.e...
Background: 5-aminosalicylic acid (5-ASA, mesalamine) is at present the treatment of choice for Infl...
Purpose. 5-aminosalicylic acid (5-ASA) has demonstrated its potential to treat IBD (Inflammatory Bow...
5-Aminosalicylate (5-ASA; mesalamine) is the current first-line treatment for mild to moderate ulcer...
Objective: The aim of the present work was to develop new solid pharmaceutical delivery systems of m...
Introduction Recent studies prove that the number of patients with inflammatory bowel disease is inc...
Mesalazine (5-ASA) is the standard drug for the treatment of inflammatory bowel disease (IBD) due to...
Mesalazine (5-ASA) is a compound being used in the therapy of inflammatory bowel disease (IBD). Cons...
Aims: An oral multiparticulate coated formulation of 5‐aminosalicylic acid (5‐ASA; mesalazine) has b...
INTRODUCTION AND OBJECTIVES Mesalazine or 5-aminosalicylic (5-ASA), a typical antiinflatmmatory dru...
Mesalamine is a gold standard anti-inflammatory drug used to treat inflammatory bowel illnesses. It'...
Background: Multi-matrix (MMx), a new delivery system for mesalazine. seems to release 5-aminosalicy...
Objective: This study was intended to investigate the potential of the colon specificity approach co...
The small intestine is where most conventional oral formulations are mostly absorbed. This restricts...
Mesalazine (5-ASA) is an anti-inflammatory drug used for ulcerative colitis or Crohn's desease. Most...