Ibuprofen, a chiral non-steroidal anti-inflammatory drug chemically related to fenoprofen and naproxen, has moderate but definite anti-inflammatory, analgesic and antipyretic properties, with considerably less gastrointestinal adverse effect than other drugs in the same family. Currently available in the market are preparations in which bioavailability of ibuprofen is increased by salification with various salts. We have investigated the pharmacological properties of one such salt, ibuprofen-arginine, of biological interest because l-arginine acts as substrate of the nitric oxide (NO) synthesising enzymes. Using epithelial HeLa cells expressing the endothelial NO synthase we show that ibuprofen-arginine releases NO and that this NO protects...
Rheumatic diseases are the most prevalent causes of disability in western countries, and nonsteroida...
A resolutive therapy for muscular dystrophies, a heterogeneous group of genetic diseases leading to ...
1. The role of endogenous nitric oxide (NO) in adjuvant arthritis in Lewis rats has been studied by ...
: Nonsteroidal antiinflammatory drugs, including ibuprofen, are among the most commonly used medicat...
Nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, are amongst the most commonly us...
OBJECTIVE: To determine whether ibuprofen-arginine has a cyclooxygenase-independent pain modulating ...
Nonsteroidal antiinflammatory drugs like ibuprofen impede tissue repair by virtue of retarding infla...
The use of non-steroidal anti-inflammatory drugs (NSAID) for treatment of inflammatory conditions is...
1. The effects of novel nitric oxide-releasing nonsteroidal anti-inflammatory compounds (NO-NSAIDs) ...
Ibuprofen is a widely used non-steroidal anti-inflammatory drug (NSAID) that exerts analgesic and an...
Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most widely prescribed medications, but ...
Background/Aims: The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is limited by their abilit...
Nitric oxide (NO)-releasing NSAIDs are a new class of NSAID derivatives with markedly reduced gastro...
Two common non-steroidal anti-inflammatory drugs (NSAIDs) and their nitric oxide (NO) adducts were e...
Rheumatic diseases are the most prevalent causes of disability in western countries, and nonsteroida...
A resolutive therapy for muscular dystrophies, a heterogeneous group of genetic diseases leading to ...
1. The role of endogenous nitric oxide (NO) in adjuvant arthritis in Lewis rats has been studied by ...
: Nonsteroidal antiinflammatory drugs, including ibuprofen, are among the most commonly used medicat...
Nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, are amongst the most commonly us...
OBJECTIVE: To determine whether ibuprofen-arginine has a cyclooxygenase-independent pain modulating ...
Nonsteroidal antiinflammatory drugs like ibuprofen impede tissue repair by virtue of retarding infla...
The use of non-steroidal anti-inflammatory drugs (NSAID) for treatment of inflammatory conditions is...
1. The effects of novel nitric oxide-releasing nonsteroidal anti-inflammatory compounds (NO-NSAIDs) ...
Ibuprofen is a widely used non-steroidal anti-inflammatory drug (NSAID) that exerts analgesic and an...
Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most widely prescribed medications, but ...
Background/Aims: The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is limited by their abilit...
Nitric oxide (NO)-releasing NSAIDs are a new class of NSAID derivatives with markedly reduced gastro...
Two common non-steroidal anti-inflammatory drugs (NSAIDs) and their nitric oxide (NO) adducts were e...
Rheumatic diseases are the most prevalent causes of disability in western countries, and nonsteroida...
A resolutive therapy for muscular dystrophies, a heterogeneous group of genetic diseases leading to ...
1. The role of endogenous nitric oxide (NO) in adjuvant arthritis in Lewis rats has been studied by ...