Macrophages are widely distributed immune system cells that play an indispensable role in homeostasis and defense. They can be phenotypically polarized by the microenvironment to mount specific functional programs. Polarized macrophages can be broadly classified in two main groups: classically activated macrophages (or M1), whose prototypical activating stimuli are IFNgamma and LPS, and alternatively activated macrophages (or M2), further subdivided in M2a (after exposure to IL-4 or IL-13), M2b (immune complexes in combination with IL-1beta or LPS) and M2c (IL-10, TGFbeta or glucocorticoids). M1 exhibit potent microbicidal properties and promote strong IL-12-mediated Th1 responses, whilst M2 support Th2-associated effector functions. Beyond...
In response to various signals, macrophages undergo classical M1 activation (stimulated by toll-like...
Macrophages represent a heterogeneous cell population and are known to display a remarkable plastici...
The construction of an inflammatory microenvironment provides the fuel for cancer development and pr...
Macrophages are widely distributed immune system cells that play an indispensable role in homeostasi...
Macrophages are cells of the innate immunity constituting the mononuclear phagocyte system and endow...
International audienceExperimental models have often been at the origin of immunological paradigms s...
Macrophages are key cellular components of the innate immunity, acting as the main player in the fir...
International audienceMacrophages play an important role in tissue homeostasis, tissue remodeling, i...
Diversity and plasticity are hallmarks of cells of the monocyte-macrophage lineage. In response to I...
Macrophages are present in most human tissues and have very diverse functions. Activated macrophages...
Abstract Macrophages are an essential component of innate immunity and play a vital role in inflamma...
Macrophages can be polarized into M1 and M2 macrophages based on the composition of the milieu. Huma...
Experimental models have often been at the origin of immunological paradigms such as the M1/M2 dicho...
Macrophages can polarize into two different states (M1 and M2), which play contrasting roles during ...
Macrophages are dynamic cells that mature under the influence of signals from the local microenviron...
In response to various signals, macrophages undergo classical M1 activation (stimulated by toll-like...
Macrophages represent a heterogeneous cell population and are known to display a remarkable plastici...
The construction of an inflammatory microenvironment provides the fuel for cancer development and pr...
Macrophages are widely distributed immune system cells that play an indispensable role in homeostasi...
Macrophages are cells of the innate immunity constituting the mononuclear phagocyte system and endow...
International audienceExperimental models have often been at the origin of immunological paradigms s...
Macrophages are key cellular components of the innate immunity, acting as the main player in the fir...
International audienceMacrophages play an important role in tissue homeostasis, tissue remodeling, i...
Diversity and plasticity are hallmarks of cells of the monocyte-macrophage lineage. In response to I...
Macrophages are present in most human tissues and have very diverse functions. Activated macrophages...
Abstract Macrophages are an essential component of innate immunity and play a vital role in inflamma...
Macrophages can be polarized into M1 and M2 macrophages based on the composition of the milieu. Huma...
Experimental models have often been at the origin of immunological paradigms such as the M1/M2 dicho...
Macrophages can polarize into two different states (M1 and M2), which play contrasting roles during ...
Macrophages are dynamic cells that mature under the influence of signals from the local microenviron...
In response to various signals, macrophages undergo classical M1 activation (stimulated by toll-like...
Macrophages represent a heterogeneous cell population and are known to display a remarkable plastici...
The construction of an inflammatory microenvironment provides the fuel for cancer development and pr...