Synthesis of enantiopure 2-amino-1-phenyl and 2-amino-2-phenyl ethanols using enantioselective enzymatic epoxidation and regio- and diastereoselective chemical aminolysis

• Several enantiopure 1,2-amino alcs. have been prepd. by combining a stereoselective enzymic epoxidn. of styrenes with regio- and stereoselective chem. reactions. An interesting reactivity has been noted concerning the ring opening of epoxides with NH3 under microwave activation