Activity of adenosine deaminase (ADA) and adenylate deaminase (AMPDA) towards 6-chloropurine nucleosides modified in the ribose moiety
- P.Ciuffreda
- B.Buzzi
- L. Alessandrini
- E. Santaniello
Publication date
January 2004
DOI Publisher
Wiley ISSN
1434-193X Citation count (estimate)
6Abstract
The enzymes adenosine deaminase (ADA) and adenylate deaminase (AMPDA) are able to catalyze the hydrolytic dechlorination of 6-chloropurine riboside and the corresponding 2',3'-O-isopropylidene derivative, but show no activity towards the 3,4-O-isopropylidene-1-methylriboside of 6-chloropurine and adenine
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