Angiogenesis : an overview

Tissue homeostasis is dependent upon an adequate supply of oxygen and nutrients delivered through blood vessels. Since the cells must be located within 100-200 μm of blood vessels, the diffusion limit for oxygen, to survive and properly function, the maintenance of the vascular network is critical for survival of tissues. Angiogenesis, derived from the Greek word angêion meaning vase, and genesis meaning birth, is the name given to the outgrowth of new capillaries from the pre-existing primary plexus and is crucial in responding to tissue demands both in physiological and pathological conditions