Pt(IV) prodrugs are a class of promising anticancer agents, which are activated by reduction to the active Pt(II) species. Consequently, the reduction process is a crucial parameter. Herein, a new approach using electrochemistry (EC) coupled to liquid chromatography (LC) and electrospray ionization-mass spectrometry (ESI-MS) or inductively coupled plasma (ICP)-MS was applied. This enabled getting insights into the differences in the reduction and ligand release of platinum(IV) complexes with varying equatorial core structures
Platinum(IV) complexes are a promising class of pro-drugs which may bypass the problems associated w...
Aiming at reducing the unselective cytotoxicity of Pt(II) chemotherapeutics, a great deal of effort ...
International audiencePlatinum(IV) complexes are extensively studied for their activity against canc...
Kinetically inert platinum(IV) complexes are receiving growing attention as promising candidates in ...
Kinetically inert platinum(IV) complexes are receiving growing attention as promising candidates in ...
The potential advantage of platinum(IV) complexes as alternatives to classical platinum(II)-based dr...
The study of Pt(IV) antitumor prodrugs able to circumvent some drawbacks of the conventional Pt(II) ...
This article reviews approaches on platinum speciation with respect to Pt drugs in anti-cancer thera...
The putative platinum(IV) anticancer drugs, [Pt{((R)NCH(2))(2)}(py)(2)XY] (X,Y=Cl, R=p-HC(6)F(4) (1a...
The electrospray mass spectrometric (ESI-MS) behavior of the complexes trans-dichloro(ethylenediamin...
In this thesis reductions of model and anticancer active Pt(IV) complexes with thiols and ascorbic a...
Platinum(II) complexes are very important drugs in anticancer chemotherapy. Although few Pt(II) comp...
We carried out a theoretical study on the mechanism of electrochemical reduction of the prototypical...
We report the results of the quantitative structure–property relationship analysis of 31 Pt(IV) comp...
The potential advantage of platinum(IV) complexes as alternative to classical platinum(II)-based dru...
Platinum(IV) complexes are a promising class of pro-drugs which may bypass the problems associated w...
Aiming at reducing the unselective cytotoxicity of Pt(II) chemotherapeutics, a great deal of effort ...
International audiencePlatinum(IV) complexes are extensively studied for their activity against canc...
Kinetically inert platinum(IV) complexes are receiving growing attention as promising candidates in ...
Kinetically inert platinum(IV) complexes are receiving growing attention as promising candidates in ...
The potential advantage of platinum(IV) complexes as alternatives to classical platinum(II)-based dr...
The study of Pt(IV) antitumor prodrugs able to circumvent some drawbacks of the conventional Pt(II) ...
This article reviews approaches on platinum speciation with respect to Pt drugs in anti-cancer thera...
The putative platinum(IV) anticancer drugs, [Pt{((R)NCH(2))(2)}(py)(2)XY] (X,Y=Cl, R=p-HC(6)F(4) (1a...
The electrospray mass spectrometric (ESI-MS) behavior of the complexes trans-dichloro(ethylenediamin...
In this thesis reductions of model and anticancer active Pt(IV) complexes with thiols and ascorbic a...
Platinum(II) complexes are very important drugs in anticancer chemotherapy. Although few Pt(II) comp...
We carried out a theoretical study on the mechanism of electrochemical reduction of the prototypical...
We report the results of the quantitative structure–property relationship analysis of 31 Pt(IV) comp...
The potential advantage of platinum(IV) complexes as alternative to classical platinum(II)-based dru...
Platinum(IV) complexes are a promising class of pro-drugs which may bypass the problems associated w...
Aiming at reducing the unselective cytotoxicity of Pt(II) chemotherapeutics, a great deal of effort ...
International audiencePlatinum(IV) complexes are extensively studied for their activity against canc...