High clustering of acute HCV infections and high rate of associated STIs among Parisian HIV-positive male patients.
- Todesco, Eve
- Day, Nesrine
- Amiel, Corinne
- Elaerts, Stéphane
- Schneider, Véronique
- Roudière, Laurent
- Hué, Stéphane
- Liotier, Jean-Yves
- Bottero, Julie
- L'Yavanc, Thomas
- Ohayon, Michel
- Gosset, Daniel
- Thibault, Vincent
- Surgers, Laure
- Chas, Julie
- Akhavan, Sepideh
- Velter, Annie
- Katlama, Christine
- Kreplak, Georges
- Marcelin, Anne-Geneviève
- Valantin, Marc-Antoine
DOIAbstract
BACKGROUND: Increasing incidence of hepatitis C virus (HCV) infection in human immunodeficiency virus (HIV)-positive men having sex with men (MSM) has been described in recent years. Phylogenetic analyses of acute HCV infections were undertaken to characterize the dynamics during the epidemic in Paris, and associated sexually transmitted infections (STIs) were evaluated. METHODS: Sanger sequencing of polymerase gene was performed. Maximum likelihood phylogenies were reconstructed using FastTree 2.1 under a GTR+CAT model. Transmission chains were defined as clades with a branch probability ≥0.80 and intraclade genetic distances <0.02 nucleotide substitutions per sites. STIs detected ≤1 month before HCV diagnosis were considered. RESULTS: Amo...
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