The preservation (in terms of inhibition of failures and collapses) of architectural heritage against horizontal loads (such as earthquakes) requires an accurate assessment of the non-linear response up to failure: to this aim, the use of advanced numerical tools to perform three-dimensional non-linear dynamic analyses is fundamental. This paper investigates the performance (up to the activation of local failures and under horizontal loads) of three historical masonry palaces of the outstanding cultural heritage in Mantua (Northern Italy) after the 2012 Emilia earthquake. Despite the unquestionable importance of the three case studies, until now these palaces have not been studied with advanced numerical simulations; moreover, the recent se...