Circulating high sensitivity C reactive protein concentrations and risk of lung cancer : Nested case-control study within Lung Cancer Cohort Consortium
- Muller, David C.
- Larose, Tricia L.
- Hodge, Allison
- Guida, Florence
- Langhammer, Arnulf
- Grankvist, Kjell
- Meyer, Klaus
- Cai, Qiuyin
- Arslan, Alan A.
- Zeleniuch-Jacquotte, Anne
- Albanes, Demetrius
- Giles, Graham G.
- Sesso, Howard D.
- Lee, I. Min
- Gaziano, J. Michael
- Yuan, Jian Min
- Bolton, Judith Hoffman
- Buring, Julie E.
- Visvanathan, Kala
- Le Marchand, Loic
- Purdue, Mark P.
- Caporaso, Neil E.
- Midttun, Øivind
- Ueland, Per M.
- Prentice, Ross L.
- Weinstein, Stephanie J.
- Stevens, Victoria L.
- Zheng, Wei
- Blot, William J.
- Shu, Xiao Ou
- Zhang, Xuehong
- Xiang, Yong Bing
- Koh, Woon Puay
- Hveem, Kristian
- Thomson, Cynthia A.
- Pettinger, Mary
- Engström, Gunnar
- Brunnström, Hans
- Milne, Roger L.
- Stampfer, Meir J.
- Han, Jiali
- Johansson, Mikael
- Brennan, Paul
- Severi, Gianluca
- Johansson, Mattias
DOIAbstract
Objectives To conduct a comprehensive analysis of prospectively measured circulating high sensitivity C reactive protein (hsCRP) concentration and risk of lung cancer overall, by smoking status (never, former, and current smokers), and histological sub-type. Design Nested case-control study. setting 20 population based cohort studies in Asia, Europe, Australia, and the United States. ParticiPants 5299 patients with incident lung cancer, with individually incidence density matched controls. exPOsure Circulating hsCRP concentrations in prediagnostic serum or plasma samples. Main OutcOMe Measure Incident lung cancer diagnosis. results A positive association between circulating hsCRP concentration and the risk of lung cancer for current (odds r...
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