Add to ORKGThe methanol-soluble extracts of the roots of Cynanchum wilfordii showed a significant multidrug-resistance-reversing activity, and four known pregnane glycosides were isolated by bioassay-directed fractionation and separation. Their structures were identified as gagaminin 3-O-β-D- cymaropyranosyl(1→4)-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl- (1→4)-β-D-cymaropyranoside (1), wilfoside K1N (2), wilfoside C1N (3), and cynauricuoside A (4). In particular, compound 1, at a concentration level of 1 μM, was found to completely reverse the multidrug-resistance of KB-V1 and MCF7/ADR cells to adriamycin, vinblastine, and colchicine.ope
Dans le cadre de la recherche de composés pouvant stimuler la sécrétion de l’hormone hypoglycémiante...
In the framework of our search for antidiabetic compounds capable of stimulating the secretion of th...
<p>A novel dimeric flavonol glycoside, Cynanflavoside A (<b>1</b>), together with six analogues, kae...
The methanol-soluble extracts of the roots of Cynanchum wilfordii showed a significant multidrug-res...
Fig. 4. Compounds 1, 21, and 25 can reverse drug resistance by decreasing P-gp, NF-κB, and c-jun gen...
Fig. 2. NF-κB expression in breast cancer and hepatocellular carcinoma Adriamycin-resistant cell lin...
Zhang, Ludi, Yuefang, Lin, min, Huang, Wenbo, Chen, Duan, Lixin, Liu, Zhongqiu, Lu, Linlin, Zhang, R...
Five new pregnane-type steroidal glycosides, named menarandrosides A-E (1-2, 5-7) were isolated from...
Fig. 1. Structures of compounds Isolated from Cynanchum wallichii wight roots.Published as part of Z...
Nine new C<sub>21</sub> steroidal glycosides, named cynawilfosides A–I (<b>1</b>–<b>9</b>), along wi...
Fig. 3. The C21 steroid compounds (1–28) exhibited DOX resistance reversing activity (A) Cell viabil...
For our interest in the potential biologically active and structurally unique steroidal glycosides, ...
International audienceIn our continued efforts to explore the antidiabetic potential of pregnanes fr...
Methanol extracts from 450 plants were screened for multidrug-resistance reversing activity using dr...
International audienceIn the search for natural glucagon-like peptide-1 (GLP-1) secretagogues, which...
Dans le cadre de la recherche de composés pouvant stimuler la sécrétion de l’hormone hypoglycémiante...
In the framework of our search for antidiabetic compounds capable of stimulating the secretion of th...
<p>A novel dimeric flavonol glycoside, Cynanflavoside A (<b>1</b>), together with six analogues, kae...
The methanol-soluble extracts of the roots of Cynanchum wilfordii showed a significant multidrug-res...
Fig. 4. Compounds 1, 21, and 25 can reverse drug resistance by decreasing P-gp, NF-κB, and c-jun gen...
Fig. 2. NF-κB expression in breast cancer and hepatocellular carcinoma Adriamycin-resistant cell lin...
Zhang, Ludi, Yuefang, Lin, min, Huang, Wenbo, Chen, Duan, Lixin, Liu, Zhongqiu, Lu, Linlin, Zhang, R...
Five new pregnane-type steroidal glycosides, named menarandrosides A-E (1-2, 5-7) were isolated from...
Fig. 1. Structures of compounds Isolated from Cynanchum wallichii wight roots.Published as part of Z...
Nine new C<sub>21</sub> steroidal glycosides, named cynawilfosides A–I (<b>1</b>–<b>9</b>), along wi...
Fig. 3. The C21 steroid compounds (1–28) exhibited DOX resistance reversing activity (A) Cell viabil...
For our interest in the potential biologically active and structurally unique steroidal glycosides, ...
International audienceIn our continued efforts to explore the antidiabetic potential of pregnanes fr...
Methanol extracts from 450 plants were screened for multidrug-resistance reversing activity using dr...
International audienceIn the search for natural glucagon-like peptide-1 (GLP-1) secretagogues, which...
Dans le cadre de la recherche de composés pouvant stimuler la sécrétion de l’hormone hypoglycémiante...
In the framework of our search for antidiabetic compounds capable of stimulating the secretion of th...
<p>A novel dimeric flavonol glycoside, Cynanflavoside A (<b>1</b>), together with six analogues, kae...
