Sauropus Androgynus for Increasing Uterine Weight in Menopausal Women: An Experimental Study Using Animal Models

Menopause is a natural phase of life and happens in every woman who reaches a certain age. This condition has many problems, such as endometrial atrophy, which can cause abnormal bleeding. Sauropus androgynus, known as Katu Leaf, has isoflavones compound and acts as an estrogen-like agent or phytoestrogen. Isoflavone can induce cell proliferation activity in increasing endometrial thickness and uterine weight. This study was aimed to find how the is flavone compound in Sauropus androgynus can increase the uterine weight in menopausal mice as an animal model. Twenty female mice aged two months and one week were given VCD (4-Vinyl cyclohexane dioxide) to induce the atresia acceleration of ovarian follicles, then treated with Katu Leaf extract of 0, 15 and 30mg/kgBW over four weeks. The uterine weights were measured and analyzed with One Way Analysis of Variances (Anova) and further tested with Least Significance Difference in 95% confidence interval. The result showed a difference between control and treatments group (p