Kadar enzim Lipoprotein-Phospholipase a2 (LP-PLA2) dalam serum darah dan jaringan aorta pada berbagai usia tikus (Rattusnorvegicus) wistar jantan

The aims of this study are to determine the effect of age on levels of Lp-PLA2 plasma and aortic tissue rat (Rattus norvegicus) Wistar males. This research was conducted using a quasi-experimental methods, measurement of Lp-PLA2 levels and cell count performed in rats aged 12, 14, 18 and 22weeks. Levels of Lp-PLA2 serum or tissue is determined using the Elisa method Elisa kit produce by Cusabio. Observation of foam cells was conducted using frozen slices with oil red O staining to determine the effect of treatment. Data were analyzed using ANOVA followed by LSD test and correlation analysis. The results showed that age affects the serum levelsof Lp-PLA2 very significantly (p<0.01) and significant effect on levels in aortic tissues (p