The Correlation Between Testosterone and Spermatogenic Cell on Male Wistar Rats (Ratus norwegicus) After The Treatment of Active Compunds of Pluchea indica

Pluchea indica is applicable for anti-fertility on male wistar rats. It is then necessary to conduct further study on the correlation between testosterone and spermatogenic cell after the treatment of active compounds of Pluchea indica in various dosages. This study used experimental design by experimenting on 21 male wistar rats to undergo 7 treatments and 3 repetitions. Randomized group design was employed with controlled treatment, tannin 4.7 mg, tannin 9.4 mg, tannin 14.1 mg, combination (alkaloid+tannin+flavonoid) 4.7 mg, combination (alkaloid+tannin+flavonoid) 9.4 mg and combination (alkaloid+tannin+flavonoid 14.1 mg). The correlation between testosterone and spermatogenic cell was analyzed by means of Pearson correlation and regression. The findings of this study showed that p = 0.016; r = 0.458; r square 0.209 and the regression equation Y=1707.429+247.367x. The data p < 0.05 showed that there is correlation between testosterone and spermatogenic cell on male wistar rats after the treatment of active compounds of Pluchea indica (combination of alkaloid+tannin+flavonoid) in various dosages (4.1 mg; 9.4 mg and 14.1 mg). There is correlation between the level of testosterone hormone and the number of spermatogenic cell on male wistar rats after the treatment of active compounds of Pluchea indica. The tendency is that the lower the level of testosterone hormone, the lower the number of spermatogenic cell on male wistar rats after the treatment of active compounds of Pluchea indic