The ubiquitin-dependent N-end rule pathway relates the in vivo half-life of a protein to the identity of its N-terminal residue. This proteolytic system is present in all organisms examined and has been shown to have a multitude of functions in animals and fungi. In plants, however, the functional understanding of the N-end rule pathway is only beginning. The N-end rule has a hierarchic structure. Destabilizing activity of N-terminal Asp, Glu, and (oxidized) Cys requires their conjugation to Arg by an arginyl–tRNA–protein transferase (R-transferase). The resulting N-terminal Arg is recognized by the pathway’s E3 ubiquitin ligases, called ‘‘N-recognins.’’ Here, we show that the Arabidopsis R-transferases AtATE1 and AtATE2 regulate...
Abstract Regulation of protein stability and/or degradation of misfolded and damaged proteins are es...
The Arg/N-end rule pathway of ubiquitin-mediated proteolysis has multiple functions throughout plant...
Pflanzen als sessile Organismen können Stresssituationen nicht entfliehen. Somit sind sie stärker au...
The ubiquitin-dependent N-end rule pathway relates the in vivo half-life of a protein to the identi...
The ubiquitin-dependent N-end rule pathway relates the in vivo half-life of a protein to the identit...
The control of intracellular protein homeostasis is essential for the ability of plants to grow und...
The N-end rule pathway is a protein degradation pathway that relates the stability of a protein to t...
The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal amino ac...
The N-end rule pathway of targeted protein degradation is an important regulator of diverse processe...
International audienceTo efficiently counteract pathogens, plants rely on a complex set of immune re...
The N-end rule pathway of targeted protein degradation is an important regulator of diverse processe...
The Arg/N-end rule pathway of ubiquitin-mediated proteolysis has multiple functions throughout plant...
Abstract Regulation of protein stability and/or degradation of misfolded and damaged proteins are es...
The Arg/N-end rule pathway of ubiquitin-mediated proteolysis has multiple functions throughout plant...
Pflanzen als sessile Organismen können Stresssituationen nicht entfliehen. Somit sind sie stärker au...
The ubiquitin-dependent N-end rule pathway relates the in vivo half-life of a protein to the identi...
The ubiquitin-dependent N-end rule pathway relates the in vivo half-life of a protein to the identit...
The control of intracellular protein homeostasis is essential for the ability of plants to grow und...
The N-end rule pathway is a protein degradation pathway that relates the stability of a protein to t...
The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal amino ac...
The N-end rule pathway of targeted protein degradation is an important regulator of diverse processe...
International audienceTo efficiently counteract pathogens, plants rely on a complex set of immune re...
The N-end rule pathway of targeted protein degradation is an important regulator of diverse processe...
The Arg/N-end rule pathway of ubiquitin-mediated proteolysis has multiple functions throughout plant...
Abstract Regulation of protein stability and/or degradation of misfolded and damaged proteins are es...
The Arg/N-end rule pathway of ubiquitin-mediated proteolysis has multiple functions throughout plant...
Pflanzen als sessile Organismen können Stresssituationen nicht entfliehen. Somit sind sie stärker au...