State Reconstruction in Spatially Distributed BioProcess Systems using Reduced Order Models: Application to the Gluconic Acid Production.

In this work, the dissipative nature of spatially distributed bioprocess systems is exploited to develop efficient state observers based on a low dimensional dynamic representation of the original set of partial differential equations. The approach we suggest combines standard observer design techniques for bioreactors with efficient model reduction methodologies based on projection of the original concentration fields on low dimensional subspaces capturing the slow dynamics of the process. Aspects related with the location of sensors and their influence on the ability to reconstruct concentration fields will also be considered. Finally, the different aspects of the methodology, as well as the efficiency of the resulting observers will be illustrated on a case study of industrial interest, namely a tubular bioreactor producing gluconic acid by Aspergillus Niger