Viral proteins are a potential candidate for subunit vaccine development as they are able to self-assemble into an authentic structure without the existence of an infectious genome. However, its poor immunogenicity limits its applications for vaccine delivery. Therefore, this work aims to develop an antigen-adjuvant complex to increase the immune response and cell viability with viral proteins, as well as investigate the mechanism of inflammasome signaling with the antigen-adjuvant complex in vitro. Simian Virus 40 viral protein 1 (SV40 VP1) viral protein with a size of ~20 nm in diameter was produced as a recombinant protein using a baculovirus expression vector system, and verified using SDS-Page and Western Blot analysis. SV40 VP1 was t...
Recombinant antigens hold high potential to develop vaccines against lethal intracellular pathogens ...
of 0.95 already indicates that vesicles are formed, which can be confirmed by cryoTEM. Loaded PeptoS...
University of Minnesota Ph.D. dissertation. June 2011. Major:Biomedical Engineering. Advisor: Chun W...
Viral proteins are a potential candidate for subunit vaccine development as they are able to self-as...
In this study, we demonstrate how encapsulating a conserved influenza ectodomain matrix-2 protein vi...
Thesis (Ph.D.)--University of Washington, 2014The key aspect of a vaccine delivery platform is to be...
Subunit viral vaccines are typically not as efficient as live attenuated or inactivated vaccines at ...
Objective(s): In the current work, poly D, L lactide-co-glycolide (PLGA) particles were applied for ...
Design and application of epitope-based polyvalent vaccines have recently garnered attention as an e...
Vaccination represents one of the most cost-effective methods for the treatment and prevention of di...
Virosomes are reconstituted viral membranes in which protein can be encapsulated. Fusion-active viro...
Many viral structural proteins are capable of spontaneously self-assembling into structures that res...
Successful delivery of labile vaccine antigens, such as peptides and proteins, to stimulate CD4 and ...
<p>The use of biomaterials and nanosystems in antigen delivery has played a major role in the develo...
available in PMC 2011 September 1Vaccines based on recombinant proteins avoid the toxicity and antiv...
Recombinant antigens hold high potential to develop vaccines against lethal intracellular pathogens ...
of 0.95 already indicates that vesicles are formed, which can be confirmed by cryoTEM. Loaded PeptoS...
University of Minnesota Ph.D. dissertation. June 2011. Major:Biomedical Engineering. Advisor: Chun W...
Viral proteins are a potential candidate for subunit vaccine development as they are able to self-as...
In this study, we demonstrate how encapsulating a conserved influenza ectodomain matrix-2 protein vi...
Thesis (Ph.D.)--University of Washington, 2014The key aspect of a vaccine delivery platform is to be...
Subunit viral vaccines are typically not as efficient as live attenuated or inactivated vaccines at ...
Objective(s): In the current work, poly D, L lactide-co-glycolide (PLGA) particles were applied for ...
Design and application of epitope-based polyvalent vaccines have recently garnered attention as an e...
Vaccination represents one of the most cost-effective methods for the treatment and prevention of di...
Virosomes are reconstituted viral membranes in which protein can be encapsulated. Fusion-active viro...
Many viral structural proteins are capable of spontaneously self-assembling into structures that res...
Successful delivery of labile vaccine antigens, such as peptides and proteins, to stimulate CD4 and ...
<p>The use of biomaterials and nanosystems in antigen delivery has played a major role in the develo...
available in PMC 2011 September 1Vaccines based on recombinant proteins avoid the toxicity and antiv...
Recombinant antigens hold high potential to develop vaccines against lethal intracellular pathogens ...
of 0.95 already indicates that vesicles are formed, which can be confirmed by cryoTEM. Loaded PeptoS...
University of Minnesota Ph.D. dissertation. June 2011. Major:Biomedical Engineering. Advisor: Chun W...