Add to ORKGΔ(4)-Abiraterone (D4A) is a recently discovered active metabolite of the oral anti-androgen drug abiraterone acetate. For quantification of this metabolite in human plasma, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated. Human plasma samples of patients treated with abiraterone acetate were prepared by protein precipitation with acetonitrile. The method was validated over a linear range of 0.2-20ng/mL. Intra-assay and inter-assay variabilities were within ±15% of the nominal concentrations for quality control (QC) samples at medium and high concentrations and within ±20% at the lower limit of quantification (LLOQ), respectively. The described method for quantification of D4A was validated succ...
Clinical Practice Points • Abiraterone acetate, which is metabolized in the liver, is a well-establi...
Background: With liquid chromatography-tandem mass spectrometry (LC-MS/MS) increasingly being used f...
11-Oxygenated androgens (11-OAs) are being discussed as potential biomarkers in diagnosis and therap...
Δ(4)-Abiraterone (D4A) is a recently discovered active metabolite of the oral anti-androgen drug abi...
A method was developed and validated to quantify abiraterone in human plasma. During assay developme...
BACKGROUND: Abiraterone acetate and enzalutamide are 2 novel drugs for the treatment of metastatic c...
Abiraterone acetate (AA), the prodrug of abiraterone, is FDA-approved for the treatment of castratio...
A liquid chromatography-mass spectrometry assay was developed and validated for simultaneous quantif...
BACKGROUND: Abiraterone acetate is an oral 17α-hydroxylase/C17,20-lyase (CYP17) inhibitor approved f...
Prostate cancer is the most common malignancy among men in the Western world. Treatment of this pati...
Item does not contain fulltextInhibiting the androgen receptor (AR) pathway is an important clinical...
The aim of the proposed work was to develop and validate a simple and sensitive assay for the analys...
A new automated method for the quantitative analysis of cyproterone acetate (CPA) in human plasma ha...
A specific, fast and sensitive high performance liquid chromatography (HPLC) coupled to atmospheric ...
The physiological and pathological development of the breast is strongly affected by the hormonal mi...
Clinical Practice Points • Abiraterone acetate, which is metabolized in the liver, is a well-establi...
Background: With liquid chromatography-tandem mass spectrometry (LC-MS/MS) increasingly being used f...
11-Oxygenated androgens (11-OAs) are being discussed as potential biomarkers in diagnosis and therap...
Δ(4)-Abiraterone (D4A) is a recently discovered active metabolite of the oral anti-androgen drug abi...
A method was developed and validated to quantify abiraterone in human plasma. During assay developme...
BACKGROUND: Abiraterone acetate and enzalutamide are 2 novel drugs for the treatment of metastatic c...
Abiraterone acetate (AA), the prodrug of abiraterone, is FDA-approved for the treatment of castratio...
A liquid chromatography-mass spectrometry assay was developed and validated for simultaneous quantif...
BACKGROUND: Abiraterone acetate is an oral 17α-hydroxylase/C17,20-lyase (CYP17) inhibitor approved f...
Prostate cancer is the most common malignancy among men in the Western world. Treatment of this pati...
Item does not contain fulltextInhibiting the androgen receptor (AR) pathway is an important clinical...
The aim of the proposed work was to develop and validate a simple and sensitive assay for the analys...
A new automated method for the quantitative analysis of cyproterone acetate (CPA) in human plasma ha...
A specific, fast and sensitive high performance liquid chromatography (HPLC) coupled to atmospheric ...
The physiological and pathological development of the breast is strongly affected by the hormonal mi...
Clinical Practice Points • Abiraterone acetate, which is metabolized in the liver, is a well-establi...
Background: With liquid chromatography-tandem mass spectrometry (LC-MS/MS) increasingly being used f...
11-Oxygenated androgens (11-OAs) are being discussed as potential biomarkers in diagnosis and therap...