Add to ORKGActivation of the DNA-damage response can lead to the induction of an arrest at various stages in the cell cycle. These arrests are reversible in nature, unless the damage is too excessive. Here we find that checkpoint reversibility is lost in cells that are in very late G2, but not yet fully committed to enter mitosis (antephase). We show that antephase cells exit the cell cycle and enter senescence at levels of DNA damage that induce a reversible arrest in early G2. We show that checkpoint reversibility critically depends on the presence of the APC/C inhibitor Emi1, which is degraded just before mitosis. Importantly, ablation of the cell cycle withdrawal mechanism in antephase promotes cell division in the presence of broken chromosomes. ...
In response to genotoxic stress, which can be caused by environmental or endogenous genotoxic insult...
In response to DNA damage, cells arrest at specific stages in the cell cycle. This arrest must fulfi...
In response to DNA damage, cells arrest at specific stages in the cell cycle. This arrest must fulfi...
Activation of the DNA-damage response can lead to the induction of an arrest at various stages in th...
Cells form the basis for all living organisms on earth. All genetic information needed for a cell to...
Cells form the basis for all living organisms on earth. All genetic information needed for a cell to...
Double-stranded DNA breaks activate a DNA damage checkpoint in G2 phase to trigger a cell cycle arre...
Double-stranded DNA breaks activate a DNA damage checkpoint in G2 phase to trigger a cell cycle arre...
In order to maintain genetic integrity, cells are equipped with cell cycle checkpoints that detect D...
In order to maintain genetic integrity, cells are equipped with cell cycle checkpoints that detect D...
Cells are equipped with a cell-intrinsic signaling network called the DNA damage response (DDR). Thi...
Cells are equipped with a cell-intrinsic signaling network called the DNA damage response (DDR). Thi...
Cells are equipped with a cell-intrinsic signaling network called the DNA damage response (DDR). Thi...
Human cells that suffer mild DNA damage can enter a reversible state of growth arrest known as quies...
The maintenance of genome integrity is important for normal cellular functions, organism development...
In response to genotoxic stress, which can be caused by environmental or endogenous genotoxic insult...
In response to DNA damage, cells arrest at specific stages in the cell cycle. This arrest must fulfi...
In response to DNA damage, cells arrest at specific stages in the cell cycle. This arrest must fulfi...
Activation of the DNA-damage response can lead to the induction of an arrest at various stages in th...
Cells form the basis for all living organisms on earth. All genetic information needed for a cell to...
Cells form the basis for all living organisms on earth. All genetic information needed for a cell to...
Double-stranded DNA breaks activate a DNA damage checkpoint in G2 phase to trigger a cell cycle arre...
Double-stranded DNA breaks activate a DNA damage checkpoint in G2 phase to trigger a cell cycle arre...
In order to maintain genetic integrity, cells are equipped with cell cycle checkpoints that detect D...
In order to maintain genetic integrity, cells are equipped with cell cycle checkpoints that detect D...
Cells are equipped with a cell-intrinsic signaling network called the DNA damage response (DDR). Thi...
Cells are equipped with a cell-intrinsic signaling network called the DNA damage response (DDR). Thi...
Cells are equipped with a cell-intrinsic signaling network called the DNA damage response (DDR). Thi...
Human cells that suffer mild DNA damage can enter a reversible state of growth arrest known as quies...
The maintenance of genome integrity is important for normal cellular functions, organism development...
In response to genotoxic stress, which can be caused by environmental or endogenous genotoxic insult...
In response to DNA damage, cells arrest at specific stages in the cell cycle. This arrest must fulfi...
In response to DNA damage, cells arrest at specific stages in the cell cycle. This arrest must fulfi...