Generalized complex geometry is a theory that unifies complex geometry and symplectic geometry into one single framework. It was introduced by Hitchin and Gualtieri around 2002. In this thesis we address the following question: given a generalized complex manifold together with a submanifold, does the blow-up of that submanifold admit again a generalized complex structure? We give the following answers to this question: If the directions that are normal to the submanifold are purely complex, then the blow-up admits a generalized complex structure for which the blow-down map is generalized holomorphic if and only if the induced Lie algebra on the conormal bundle of the submanifold is degenerate. This is a rather restrictive condition, but it...