Using data from the ISTAT-RS1 Survey we explore inward and outward R&D activities of different categories of firms resident in Italy in 2001-2010. From this perspective we provide detailed evidence of the role played by this country in the global creation and transmission of technology. First, foreign owned multinationals are the most active in cross-border transactions of knowledge but hold a low and decreasing share in national R&D expenditure. This trend reveals on the one hand that the Italian economy is a poorer and poorer attractor of high value added investments from abroad; and on the other hand that national companies, and particularly local SMEs not belonging to international groups, have significantly increased their R&D efforts ...