Telomerase reverse transcriptase (TERT) and telomerase RNA component (TERC) constitute the core telomerase enzyme that maintains the length of telomeres. Telomere maintenance is affected in a broad range of cancer and degenerative disorders. Taking advantage of gain- and loss-of-function approaches, we show that Argonaute 2 (AGO2) promotes telomerase activity and stimulates the association between TERT and TERC. AGO2 depletion results in shorter telomeres as well as in lower proliferation rates in vitro and in vivo. We also demonstrate that AGO2 interacts with TERC and with a newly identified sRNA (terc-sRNA), arising from the H/ACA box of TERC. Notably, terc-sRNA is sufficient to enhance telomerase activity when overexpressed. Analyses of ...
studies on chromosome termini (telomeres) and their discovery of telomerase, the enzyme that syn-the...
RNA polymerase II transcribes the physical ends of linear eukaryotic chromosomes into a variety of l...
To perform their regulatory functions, microRNAs (miRNAs) must assemble with any of the four mammali...
Telomerase reverse transcriptase (TERT) and telomerase RNA component (TERC) constitute the core telo...
Human telomerase holoenzyme consists of the catalytic component TERT and the template RNA TERC. Howe...
The telomerase ribonucleoprotein complex has a pivotal role in regulating the proliferation and sene...
Substantial fraction of high-quality information is continuously being added into the existing pool ...
To perform their regulatory functions, microRNAs (miRNAs) must assemble with any of the four mammali...
The members of the Argonaute (AGO) protein family are key players in miRNA-guided gene silencing. Th...
Small interfering RNAs (siRNAs) are small RNA molecules that have a potent, sequence-specific gene ...
Human telomerase reverse transcriptase (hTERT) remains suppressed in most normal somatic cells. Resu...
The members of the Argonaute (AGO) protein family are key players in miRNA-guided gene silencing. Th...
RNA polymerase II transcribes the physical ends of linear eukaryotic chromosomes into a variety of l...
<div><p>Telomerase is expressed in early human development and then becomes silenced in most normal ...
Telomeres cap the ends of eukaryotic chromosomes and are indispensable chromatin structures for geno...
studies on chromosome termini (telomeres) and their discovery of telomerase, the enzyme that syn-the...
RNA polymerase II transcribes the physical ends of linear eukaryotic chromosomes into a variety of l...
To perform their regulatory functions, microRNAs (miRNAs) must assemble with any of the four mammali...
Telomerase reverse transcriptase (TERT) and telomerase RNA component (TERC) constitute the core telo...
Human telomerase holoenzyme consists of the catalytic component TERT and the template RNA TERC. Howe...
The telomerase ribonucleoprotein complex has a pivotal role in regulating the proliferation and sene...
Substantial fraction of high-quality information is continuously being added into the existing pool ...
To perform their regulatory functions, microRNAs (miRNAs) must assemble with any of the four mammali...
The members of the Argonaute (AGO) protein family are key players in miRNA-guided gene silencing. Th...
Small interfering RNAs (siRNAs) are small RNA molecules that have a potent, sequence-specific gene ...
Human telomerase reverse transcriptase (hTERT) remains suppressed in most normal somatic cells. Resu...
The members of the Argonaute (AGO) protein family are key players in miRNA-guided gene silencing. Th...
RNA polymerase II transcribes the physical ends of linear eukaryotic chromosomes into a variety of l...
<div><p>Telomerase is expressed in early human development and then becomes silenced in most normal ...
Telomeres cap the ends of eukaryotic chromosomes and are indispensable chromatin structures for geno...
studies on chromosome termini (telomeres) and their discovery of telomerase, the enzyme that syn-the...
RNA polymerase II transcribes the physical ends of linear eukaryotic chromosomes into a variety of l...
To perform their regulatory functions, microRNAs (miRNAs) must assemble with any of the four mammali...