Serine proteases constitute the major protein content of mast cell secretory granules. Here we present the extended cleavage specificity of two such proteases from the golden hamster, Mesocricetus auratus. Analysis by phage display technique showed that one of them (HAM1) is a classical chymase with a specificity similar to the human mast cell chymase. However, in contrast to the human chymase, it does not seem to have a particular preference for any of the three aromatic amino acids, Phe, Tyr and Trp, in the P1 position of substrates. HAM1 also efficiently cleaved after Leu similarly to human and many other mast cell chymases. We observed only a 3-fold lower cleavage activity on Leu compared to substrates with P1 aromatic amino acids. Chym...
Chymase is a specific protease of mast cells (MC) with variable expression and is one of the preform...
Mast cells are innate immune cells, historically involved in allergy responses involving IgE. Throug...
Mast cells are key effector cells in allergic and inflammatory diseases. However, their primary role...
Serine proteases constitute the major protein content of mast cell secretory granules. Here we prese...
Serine proteases constitute the major protein content of mast cell secretory granules. Here we prese...
Mast cells (MC) are potent inflammatory cells that are known primarily for their prominent role in I...
Serine proteases constitute the major protein content of mast cell (MC) secretory granules. These pr...
Mast cells (MCs) are inflammatory cells primarily found in tissues in close contact with the externa...
Immune cells like NK cells, T cells, neutrophils and mast cells store high amounts of granule serine...
It is well established that mast cells (MC) are key players in airway pathologies such as allergic a...
Mouse mast cell chymases are granule-associated serine proteinases with chymotrypsin-like substrate ...
Proteases are stored in very large amounts within abundant cytoplasmic granules of mast cells (MCs),...
AbstractThe term chymase is used to signify a chymotrypsin-like protease stored within the secretory...
Mast cell chymases and tryptases are major constituents of mast cell granules exhibiting an intrigui...
Mast cells are rich in proteases, which are the major proteins of intracellular granules and are rel...
Chymase is a specific protease of mast cells (MC) with variable expression and is one of the preform...
Mast cells are innate immune cells, historically involved in allergy responses involving IgE. Throug...
Mast cells are key effector cells in allergic and inflammatory diseases. However, their primary role...
Serine proteases constitute the major protein content of mast cell secretory granules. Here we prese...
Serine proteases constitute the major protein content of mast cell secretory granules. Here we prese...
Mast cells (MC) are potent inflammatory cells that are known primarily for their prominent role in I...
Serine proteases constitute the major protein content of mast cell (MC) secretory granules. These pr...
Mast cells (MCs) are inflammatory cells primarily found in tissues in close contact with the externa...
Immune cells like NK cells, T cells, neutrophils and mast cells store high amounts of granule serine...
It is well established that mast cells (MC) are key players in airway pathologies such as allergic a...
Mouse mast cell chymases are granule-associated serine proteinases with chymotrypsin-like substrate ...
Proteases are stored in very large amounts within abundant cytoplasmic granules of mast cells (MCs),...
AbstractThe term chymase is used to signify a chymotrypsin-like protease stored within the secretory...
Mast cell chymases and tryptases are major constituents of mast cell granules exhibiting an intrigui...
Mast cells are rich in proteases, which are the major proteins of intracellular granules and are rel...
Chymase is a specific protease of mast cells (MC) with variable expression and is one of the preform...
Mast cells are innate immune cells, historically involved in allergy responses involving IgE. Throug...
Mast cells are key effector cells in allergic and inflammatory diseases. However, their primary role...