The fact that physical laws often admit certain kinds of space-time symmetries is often thought to be problematic for substantivalism --- the view that space-time is as real as the objects it contains. The most prominent alternative, relationism, avoids these problems but at the cost of giving abstract objects (rather than space-time points) a pivotal role in the fundamental metaphysics. This incurs related problems concerning the relation of the physical to the mathematical. In this paper I will present a version of substantivalism that respects Leibnizian theses about space-time symmetries, and argue that it is superior to both relationism and the more orthodox form of substantivalism