Molecular insights into vascular aging.

Aging of the vasculature is the leading risk factor for cardiovascular and cerebrovascular disease [1]. As such, strategies that delay vascular aging could minimize the risk of developing life-threatening vascular complications, enhance healthspan and prolong lifespan. However, such preventative and therapeutic approaches require identification of the pathophysiological changes underlying vascular aging, and the associated molecular mechanisms responsible.This work was supported by Briitsh Heart Foundation grants BHF) grants PG/13/25/30014, PG/14/69/31032, PG/16/63/32307 and RG/13/14/30314, the National Institute for Health Research Cambridge Biomedical Research Centre, the BHF Centre for Research Excellence