Neurokinin B (NKB) signaling is critical for reproduction in all studied species. The existing consensus is that NKB induces GnRH release via kisspeptin (Kiss1) stimulation in the arcuate nucleus. However, the stimulatory action of NKB is dependent on circulating estrogen (E2) levels, without which, NKB inhibits luteinizing hormone (LH) release. Importantly, the evidence supporting the kisspeptin-dependent role of NKB, derives from models of persistent hypogonadal state [e.g. Kiss1r knock-out (KO) mice], with reduced E2 levels. Here, we demonstrate that in the presence of E2, NKB signaling induces LH release in a kisspeptin-independent manner through the activation of NK3R (NKB receptor) neurons in the posterodorsal medial amygdala (MePD). ...
Reproductive function is regulated by the hypothalamic-pituitary-gonads (HPG) axis. Hypothalamic neu...
BACKGROUND/AIMS : The medial amygdala (MeA) responds to olfactory stimuli and alters reproductive ph...
Background/Aims: The medial amygdala (MeA) responds to olfactory stimuli and alters reproductive phy...
The tachykinin neurokinin B (NKB, Tac2) is critical for proper GnRH release in mammals, however, the...
PubMedID: 20041982Growing evidence suggests the tachykinin neurokinin B (NKB) may modulate gonadotro...
Kisspeptin (Kiss1) and neurokinin B (NKB) (encoded by the Kiss1 and Tac2 genes, respectively) are in...
Tachykinins are comprised of the family of related peptides, substance P (SP), neurokinin A (NKA), a...
Kisspeptin (encoded by Kiss1), a neuropeptide critically involved in neuroendocrine regulation of re...
Tachykinins are comprised of the family of related peptides, substance P (SP), neurokinin A (NKA), a...
Kisspeptin is a potent activator of GnRH-induced gonadotropin secretion and is a proposed central re...
Background/Aims: The medial amygdala (MeA) responds to olfactory stimuli and alters reproductive phy...
Pulsatile secretion of the gonadotropin-releasing hormone (GnRH) drives pulsatile secretion of the l...
Kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged as key play...
Pulsatile gonadotropin-releasing hormone (GnRH) is crucial to normal reproductive function and abnor...
Pulsatile gonadotropin-releasing hormone (GnRH) is crucial to normal reproductive function and abnor...
Reproductive function is regulated by the hypothalamic-pituitary-gonads (HPG) axis. Hypothalamic neu...
BACKGROUND/AIMS : The medial amygdala (MeA) responds to olfactory stimuli and alters reproductive ph...
Background/Aims: The medial amygdala (MeA) responds to olfactory stimuli and alters reproductive phy...
The tachykinin neurokinin B (NKB, Tac2) is critical for proper GnRH release in mammals, however, the...
PubMedID: 20041982Growing evidence suggests the tachykinin neurokinin B (NKB) may modulate gonadotro...
Kisspeptin (Kiss1) and neurokinin B (NKB) (encoded by the Kiss1 and Tac2 genes, respectively) are in...
Tachykinins are comprised of the family of related peptides, substance P (SP), neurokinin A (NKA), a...
Kisspeptin (encoded by Kiss1), a neuropeptide critically involved in neuroendocrine regulation of re...
Tachykinins are comprised of the family of related peptides, substance P (SP), neurokinin A (NKA), a...
Kisspeptin is a potent activator of GnRH-induced gonadotropin secretion and is a proposed central re...
Background/Aims: The medial amygdala (MeA) responds to olfactory stimuli and alters reproductive phy...
Pulsatile secretion of the gonadotropin-releasing hormone (GnRH) drives pulsatile secretion of the l...
Kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged as key play...
Pulsatile gonadotropin-releasing hormone (GnRH) is crucial to normal reproductive function and abnor...
Pulsatile gonadotropin-releasing hormone (GnRH) is crucial to normal reproductive function and abnor...
Reproductive function is regulated by the hypothalamic-pituitary-gonads (HPG) axis. Hypothalamic neu...
BACKGROUND/AIMS : The medial amygdala (MeA) responds to olfactory stimuli and alters reproductive ph...
Background/Aims: The medial amygdala (MeA) responds to olfactory stimuli and alters reproductive phy...