Product quality attributes are critical to the therapeutic activity of manufactured biologics. One key quality attribute is glycosylation, which can dramatically affect antibody activity, specificity, and/or immunogenicity. As such, a high priority during drug development is to control the glycosylation profile. Glycosylation is significantly influenced by the composition of cell culture media, including sugars, amino acids, vitamins, trace metals, and even metabolic waste products. Formulation of chemically-defined growth and feed media provides the ability to fine tune the concentrations of media components that regulate glycosylation through metabolic shifts and cell signaling. For example, some of the current strategies for modulat...
Glycosylation is a critical quality attribute of biopharmaceuticals because it is a major source of ...
Two fundamental objectives of bioprocess engineering are to increase productivity and improve produc...
For more than 20 years, the industry has mainly invested in productivity enhancements. Recently, the...
Product quality attributes are critical to the therapeutic activity of manufactured biologics. One k...
The extent and pattern of glycosylation can influence pharmacokinetics and effector functions of the...
Glycosylation of recombinant proteins is one of the key product quality attribute that is closely mo...
Background and novelty A large number of recent publications demonstrate the effect of cell culture ...
To address the needs of the growing antibody market, it is crucial to develop robust and efficient f...
Biologics, including antibodies, hormones and cytokines, represent an increasingly important class o...
N-linked glycans affect important end-use characteristics such as the bioactivity and efficacy of ma...
The use of feed media during protein production is essential to sustain viable cell densities and fa...
N-linked glycosylation affects the potency, safety, immunogenicity, and pharmacokinetic clearance of...
Glycosylation can be a critical quality attribute (CQA) in biologic manufacturing. In particular, it...
Microcarriers are widely used for the large-scale culture of attachment-dependent cells with increas...
Glycosylation can be a critical quality attribute (CQA) in biologic manufacturing. In particular, it...
Glycosylation is a critical quality attribute of biopharmaceuticals because it is a major source of ...
Two fundamental objectives of bioprocess engineering are to increase productivity and improve produc...
For more than 20 years, the industry has mainly invested in productivity enhancements. Recently, the...
Product quality attributes are critical to the therapeutic activity of manufactured biologics. One k...
The extent and pattern of glycosylation can influence pharmacokinetics and effector functions of the...
Glycosylation of recombinant proteins is one of the key product quality attribute that is closely mo...
Background and novelty A large number of recent publications demonstrate the effect of cell culture ...
To address the needs of the growing antibody market, it is crucial to develop robust and efficient f...
Biologics, including antibodies, hormones and cytokines, represent an increasingly important class o...
N-linked glycans affect important end-use characteristics such as the bioactivity and efficacy of ma...
The use of feed media during protein production is essential to sustain viable cell densities and fa...
N-linked glycosylation affects the potency, safety, immunogenicity, and pharmacokinetic clearance of...
Glycosylation can be a critical quality attribute (CQA) in biologic manufacturing. In particular, it...
Microcarriers are widely used for the large-scale culture of attachment-dependent cells with increas...
Glycosylation can be a critical quality attribute (CQA) in biologic manufacturing. In particular, it...
Glycosylation is a critical quality attribute of biopharmaceuticals because it is a major source of ...
Two fundamental objectives of bioprocess engineering are to increase productivity and improve produc...
For more than 20 years, the industry has mainly invested in productivity enhancements. Recently, the...