Induced Heat Property of Polyethyleneglycol-Coated Iron Oxide Nanoparticles with Dispersion Stability for Hyperthermia

Fe3O4 nanoparticles have been used for hyperthermia treatment in an attempt to overcome Various problems. When using hyperthermia treamtment, it is critical to control the surface modification of the particles. Magnetic nanoparticles tend to aggregate due to strong magnetic dipole dipole attractions. The particles then have a high surface area and are of larger sizes, posing serious practical limitations. The nanoparticles are used to generate maximum heat and to maintain a constant heating temperature using the minimum magnetic nanoparticles dosage. In this study, we investigated the effect of PEG coated onto Fe3O4 nanoparticles. We tested the dispersion stability and repetitive heating property of nanoparticles for different PEG concentrations under an AC magnetic field. The results confirmed that the nanoparticles on a colloidal system maintained the heating properties of repetitve inductive heating as PEG concentration increased with dispersion stability. The nanoparticles with superior dispersion stability will be appropriate for hyperthermia applications in cancer treatments.This study was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (R11-2008-044-01001-0) and the Pioneer Research Center Program through the National Research Foundation of Korea (2011-0001645) funded by the Ministry of Education, Science and Technology (MEST)