The effects of regular exercise on the apoptotic factor in kidney of hypertensive rats

Aerobic exercise has been induced expression of HSP70 protein metabolism and to prevent damage and reduce apoptosis. Thus, the present study is aimed to investigate the relationship between long-term EX and hypertension induced by L-NAME using HSP70, and detection of apoptotic cells in hypertensive rat kidney. Sprague-Dawley rats (n=40) were divided into 4 groups as follows: control group (Con, n=10), EX group (Ex, n=10), L-NAME treatment group (L-Con, n=10) and L-NAME treatment with EX group (L+Ex, n=10). To induce hypertension L-NAME was injected intraperitoneally, and swimming as EX was performed. HSP70 showed L-Ex, EX, L-con, Con, in kidney. In addition, apoptotic cells were more decreased in L-Ex than in L-con group. Consequently, long term EX inhibits apoptosis and any thesis HSP70 in the kidney of L-NAME induced hypertensive rats. These results suggest that EX should prevent renal damage from long-term hypertension. HSP70 expression during aerobic exercise is losing influence in the cell is self defeating argument, hypertension and kidney damage apoptosis think should be able to prevent