Pt-Catalyzed Hydrative Cyclization of 2-Enynylbenzaldehydes and Its Application to Faveline Synthesis

Various 2-[6-en-1-ynyl]benzaldehydes and their analogues were successfully cyclized via Huisgen-type [3+2] cycloaddition to the tetracyclic platinum-carbene complex, which would subsequently undergo hydration to afford the tricyclic products in good yields with excellent stereoselectivities. This hydrative cyclization was also applied to the faveline synthesis.We would like to thank the National Research Foundation of Korea (NRF 31200900000001607) for financial support and BK21 for fellowships