MMTV-neu transgenic mice overexpressing NEU in their mammary glands develop tumor after 6 months of age. To find a novel protein biomarker using this mouse model, we identified and characterized the proteins that were differently expressed between primary mammary epithelial cells from 2 months old MMTV-neu heterozygote mice and wild type (WT) littermates using two-dimensional digest (ChemDigest (TM)/Trypsin)-LC-MS/MS. The differentially expressed proteins were selected and analyzed using DAVID Bioinformatics resource. The proteins involved in anti-apoptosis, purine metabolism, ribosome and proteasome functions were upregulated, whereas cell adhesion-related proteins were downregulated in PMECs from MMTV-neu mice when compared with WT PMECs....
INTRODUCTION: Molecular characterization of the normal epithelial cell types that reside in the mamm...
openBreast Cancer is the most frequent cancer among women worldwide. The oncogene HER2 is amplified ...
The mouse mammary gland develops mainly postnatally by highly regulated phases of invasive growth, d...
MMTV-neu transgenic mice overexpressing NEU in their mammary glands develop tumor after 6 months of ...
none13The prevention of mammary carcinoma by immunological strategies targeting the HER-2/neu recept...
Background: TGF-\u3b2 acts as an antiproliferative factor in normal epithelial cells and at early st...
After lactation, the mouse mammary gland undergoes apoptosis and tissue remodelling as the gland rev...
Abstract Background TGF-β acts as an antiproliferative factor in normal epithelial cells and at earl...
Expansion of Gr-1+/CD11b+ myeloid derived suppressor cells (MDSCs) is governed by the presence of in...
We previously showed that a vaccine combining interleukin 12 and allogeneic p185(neu)-positive mamma...
<p>(A) The number 4 mammary glands from Shp1 fl/+ (control), Shp1 fl/+/;MMTV-Cre, and MMTV-Cre mice ...
BackgroundIn human breast cancer normal mammary cells typically develop into hyperplasia, ductal car...
The mammary gland undergoes extensive tissue remodelling during each lactation cycle. During pregnan...
www.tcrt.org Wnt-1 and Neu collaborate to induce mammary tumors in bitransgenic mice carrying both M...
INTRODUCTION: Mammary tumors in mice are categorized by using morphologic and architectural criteria...
INTRODUCTION: Molecular characterization of the normal epithelial cell types that reside in the mamm...
openBreast Cancer is the most frequent cancer among women worldwide. The oncogene HER2 is amplified ...
The mouse mammary gland develops mainly postnatally by highly regulated phases of invasive growth, d...
MMTV-neu transgenic mice overexpressing NEU in their mammary glands develop tumor after 6 months of ...
none13The prevention of mammary carcinoma by immunological strategies targeting the HER-2/neu recept...
Background: TGF-\u3b2 acts as an antiproliferative factor in normal epithelial cells and at early st...
After lactation, the mouse mammary gland undergoes apoptosis and tissue remodelling as the gland rev...
Abstract Background TGF-β acts as an antiproliferative factor in normal epithelial cells and at earl...
Expansion of Gr-1+/CD11b+ myeloid derived suppressor cells (MDSCs) is governed by the presence of in...
We previously showed that a vaccine combining interleukin 12 and allogeneic p185(neu)-positive mamma...
<p>(A) The number 4 mammary glands from Shp1 fl/+ (control), Shp1 fl/+/;MMTV-Cre, and MMTV-Cre mice ...
BackgroundIn human breast cancer normal mammary cells typically develop into hyperplasia, ductal car...
The mammary gland undergoes extensive tissue remodelling during each lactation cycle. During pregnan...
www.tcrt.org Wnt-1 and Neu collaborate to induce mammary tumors in bitransgenic mice carrying both M...
INTRODUCTION: Mammary tumors in mice are categorized by using morphologic and architectural criteria...
INTRODUCTION: Molecular characterization of the normal epithelial cell types that reside in the mamm...
openBreast Cancer is the most frequent cancer among women worldwide. The oncogene HER2 is amplified ...
The mouse mammary gland develops mainly postnatally by highly regulated phases of invasive growth, d...