Nanoisland-based random activation of fluorescence for visualizing endocytotic internalization of adenovirus

Super-resolution imaging is performed on metallic nanoislands by plasmonic-based activation of random near-field hot spots. Nanoislands can be synthesized to create small hotspots that spatially distinguish molecular events on the nanometer scale. Enhanced resolution is experimentally confirmed with fluorescent nanobeads, and is extended to imaging the transport of an adenovirus across a live cell membrane. �� 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim