Non-invasive Transdermal Delivery Route Using Electrostatically Interactive Biocompatible Nanocapsules

A robust means of fabricating skin-penetrating and compatible nanocarriers comprising poly(D,L-lactide-co-glycolide) is reported. The resultant nanocapsules have the ability to load biologically active ingredients and selectively release them through the epidermis lipid layer. Their release of genistein (left figure) is determined to be diffusion-control led, and they are shown to successfully deliver molecules, such as nile red (right figure), into biopsied skin samples.K.-D.S., J.H.C., and J.-W.K. equally contributed to this work as corresponding authors. This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (03-PJ1-PG1-CH14-0001). Supporting Information is available online from Wiley InterScience or from the author