International audiencePerformance optimization has become a standard approach for the design and control of energy systems, including the building sector. Contrary to the usual sequential approach, a holistic building design is more efficient since the optimum of a system can be different from the one obtained by separating its components. It is thus necessary to optimize the design by considering the building as a whole, attentive to its dynamics (envelope, system and occupants), environment, and its lifetime, particularly in the perspective of the climate change. This brings significant difficulties related to calculation time because of the combinatorial explosion, related to the decision variables and parameters uncertainties, during th...