International audienceThe present paper highlights the benefits of nanoscale characterization of the most commonly 23 used minerals – zircon and monazite – in U–Th–Pb geochronology to sharpen geochronological interpretations and convert isotopic ratios - a “date” - into a geologically meaningful age. Transmission Electron Microscopy (TEM) is a powerful analytical tool, and sometimes the only one, that can provide evidence of the mechanisms behind disturbance of the geochronological systems leading to discordance. These mechanisms include (1) distinct episodes of growth/replacement, (2) U, Th or Pb mobility (enhanced by the presence of nanostructural defects), (3) nano-inclusions or nano-chemical heterogeneity. Furthermore, TEM also helps to...