Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study
- MAFFEI, LAMBERTO
- Picano, E.
- Andreassi, M. G.
- Angelucci, A.
- Baldacci, F.
- Baroncelli, L.
- Begenisic, T.
- Bellinvia, P. F.
- Berardi, N.
- Biagi, L.
- Bonaccorsi, J.
- Bonanni, E.
- Bonuccelli, U.
- BORGHINI, ANDREA
- Braschi, C.
- Broccardi, M.
- Bruno, R. M.
- Caleo, M.
- Carlesi, C.
- Carnicelli, L.
- Cartoni, G.
- Cecchetti, L.
- Cenni, M. C.
- Ceravolo, R.
- Chico, L.
- Cintoli, S.
- Cioni, G.
- Coscia, M.
- Costa, M.
- D’Angelo, G.
- D’Ascanio, P.
- Nes, M. De
- Turco, S. Del
- Coscio, E. Di
- Galante, M. Di
- Lascio, N. di
- Faita, F.
- Falorni, I.
- Faraguna, U.
- Fenu, A.
- Fortunato, L.
- Franco, R.
- Gargani, L.
- Gargiulo, R.
- Ghiadoni, L.
- Giorgi, F. S.
- Iannarella, R.
- Iofrida, C.
- Kusmic, C.
- Limongi, F.
- Maestri, M.
- Maffei, M.
- Maggi, S.
- Mainardi, M.
- Mammana, L.
- Marabotti, A.
- Mariotti, V.
- Melissari, E.
- Mercuri, A.
- MICERA, Silvestro
- Molinaro, S.
- Narducci, R.
- Navarra, T.
- Noale, M.
- Pagni, C.
- Palumbo, S.
- Pasquariello, R.
- Pellegrini, S.
- PIETRINI, PIETRO
- Pizzorusso, T.
- Poli, A.
- Pratali, L.
- Retico, A.
- Ricciardi, E.
- Rota, G.
- Sale, A.
- Sbrana, S.
- Scabia, G.
- Scali, M.
- Scelfo, D.
- Sicari, R.
- Siciliano, G.
- Stea, F.
- Taddei, S.
- Tognoni, G.
- Tonacci, A.
- Tosetti, M.
- Turchi, S.
- Volpi, L.
DOIAbstract
Age-related cognitive impairment and dementia are an increasing societal burden. Epidemiological studies indicate that lifestyle factors, e.g. physical, cognitive and social activities, correlate with reduced dementia risk; moreover, positive effects on cognition of physical/cognitive training have been found in cognitively unimpaired elders. Less is known about effectiveness and action mechanisms of physical/cognitive training in elders already suffering from Mild Cognitive Impairment (MCI), a population at high risk for dementia. We assessed in 113 MCI subjects aged 65-89 years, the efficacy of combined physical-cognitive training on cognitive decline, Gray Matter (GM) volume loss and Cerebral Blood Flow (CBF) in hippocampus and parahippo...
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