1. 1. The analgesic effect of clonixinate of L-lysine (Clx) in the nociceptive C-fiber reflex in rat and in the writhing test in mice is reported. 2. 2. Clx was administered by three routes, i.v., i.t. and i.c.v., inducing a dose-dependent antinociception. 3. 3. The antinociceptive effect of Clx was 40-45% with respect to the control integration values in the nociceptive C-fiber reflex method. 4. 4. The writhing test yielded ED50 values (mg/kg) of 12.0 ± 1.3 (i.p.), 1.8 ± 0.2 (i.t.) and 0.9 ± 0.1 (i.c.v.) for Clx administration. 5. 5. Ondansetron was not able to antagonize the antinociception response of Clx in the algesiometric tests used. 6. 6. Chlorophenilbiguanide did not produce any significative change in the analgesic effect of Clx i...
Is there an intrinsic antinociceptive effect to explain the analgesic benefits afforded by the α2-ad...
WOS: 000084502700009PubMed ID: 10618470The effect of a leukotriene D-4 receptor antagonist, (3-(3-(2...
Objective(s): Growing evidence demonstrates that L-arginine/NO/cGMP/KATP channel pathway has a modul...
Dose-response curves for clonidine-produced analgesia in rats were constructed using the tail-flick ...
1. The antinociceptive action of clonidine (Clon) and the interactions with α1, α2 adrenoceptor and ...
1. 1. A novel vasorelaxant effect of clonixinate of l-lysine (Clx), analgesic and anti-inflammatory,...
Currently, there is an increasing need for novel analgesics that are potent but lack undesired side ...
Resiniferatoxin (RTX) is an ultrapotent synthetic TRPV1 (transient receptor potential vanilloid subt...
NG-nitro-L-arginine methyl ester (L-NAME) has been used extensively as a paradigmatic inhibitor of N...
Bunodosine 391 (BDS 391), a low molecular weight compound isolated from the sea anemone Bunodosoma c...
Background : Tricyclic antidepressants have been widely used in the treatment of chronic and acute p...
The reversal of the antinociceptive effect of systemically administered acetaminophen (paracetamol) ...
The activation of α adrenergic receptors contributes to analgesia not only in the central nervous sy...
Objectives: To test the analgesic effect of 5-HT-3 receptor antagonist, tropisetron, in a clip compr...
The regulation of nociceptive processing by 5-HT at the spinal level is intricate since the neurotra...
Is there an intrinsic antinociceptive effect to explain the analgesic benefits afforded by the α2-ad...
WOS: 000084502700009PubMed ID: 10618470The effect of a leukotriene D-4 receptor antagonist, (3-(3-(2...
Objective(s): Growing evidence demonstrates that L-arginine/NO/cGMP/KATP channel pathway has a modul...
Dose-response curves for clonidine-produced analgesia in rats were constructed using the tail-flick ...
1. The antinociceptive action of clonidine (Clon) and the interactions with α1, α2 adrenoceptor and ...
1. 1. A novel vasorelaxant effect of clonixinate of l-lysine (Clx), analgesic and anti-inflammatory,...
Currently, there is an increasing need for novel analgesics that are potent but lack undesired side ...
Resiniferatoxin (RTX) is an ultrapotent synthetic TRPV1 (transient receptor potential vanilloid subt...
NG-nitro-L-arginine methyl ester (L-NAME) has been used extensively as a paradigmatic inhibitor of N...
Bunodosine 391 (BDS 391), a low molecular weight compound isolated from the sea anemone Bunodosoma c...
Background : Tricyclic antidepressants have been widely used in the treatment of chronic and acute p...
The reversal of the antinociceptive effect of systemically administered acetaminophen (paracetamol) ...
The activation of α adrenergic receptors contributes to analgesia not only in the central nervous sy...
Objectives: To test the analgesic effect of 5-HT-3 receptor antagonist, tropisetron, in a clip compr...
The regulation of nociceptive processing by 5-HT at the spinal level is intricate since the neurotra...
Is there an intrinsic antinociceptive effect to explain the analgesic benefits afforded by the α2-ad...
WOS: 000084502700009PubMed ID: 10618470The effect of a leukotriene D-4 receptor antagonist, (3-(3-(2...
Objective(s): Growing evidence demonstrates that L-arginine/NO/cGMP/KATP channel pathway has a modul...