Sustained hypertension promotes structural, functional and metabolic remodeling of cardiomyocyte mitochondria. As long-lived, postmitotic cells, cardiomyocytes turn over mitochondria continuously to compensate for changes in energy demands and to remove damaged organelles. This process involves fusion and fission of existing mitochondria to generate new organelles and separate old ones for degradation via autophagy. Autophagy is a lysosome-dependent proteolytic pathway capable of processing cellular components, including organelles and protein aggregates. Autophagy can be either nonselective or selective and contributes to remodeling of the myocardium under stress. Fission of mitochondria, loss of membrane potential, and ubiquitination are ...
Cardiomyocytes are subjected to the intense mechanical stress and metabolic demands of the beating h...
Abstract Mitochondria are paramount to the metabolism and survival of cardiomyocytes. Here we show t...
International audienceMitochondria are paramount to the metabolism and survival of cardiomyocytes. H...
AbstractMitochondrial quality control is increasingly recognized as an essential element in maintain...
The heart is an absolutely vital body organ, which requires sufficient amount of active mitochondria...
The heart is highly sensitive to the aging process. In the elderly, the heart tends to become hypert...
The historical role of mitochondria resides in converting the energy released during the oxidation o...
The historical role of mitochondria resides in converting the energy released during the oxidation o...
Heart function maintenance requires a large amount of energy, which is supplied by the mitochondria....
The heart is highly sensitive to the aging process. In the elderly, the heart tends to become hypert...
Mitochondrial dynamics, including fission and fusion processes, are essential for heart health. Mito...
Autophagy is a major catabolic pathway by which mammalian cells degrade and recycle macromolecules a...
Autophagy is an evolutionarily conserved mechanism by which cytoplasmic elements are degraded intrac...
Artículo de publicación ISICardiac hypertrophy is often initiated as an adaptive response to haemody...
Artículo de publicación ISICardiac hypertrophy is often initiated as an adaptive response to haemody...
Cardiomyocytes are subjected to the intense mechanical stress and metabolic demands of the beating h...
Abstract Mitochondria are paramount to the metabolism and survival of cardiomyocytes. Here we show t...
International audienceMitochondria are paramount to the metabolism and survival of cardiomyocytes. H...
AbstractMitochondrial quality control is increasingly recognized as an essential element in maintain...
The heart is an absolutely vital body organ, which requires sufficient amount of active mitochondria...
The heart is highly sensitive to the aging process. In the elderly, the heart tends to become hypert...
The historical role of mitochondria resides in converting the energy released during the oxidation o...
The historical role of mitochondria resides in converting the energy released during the oxidation o...
Heart function maintenance requires a large amount of energy, which is supplied by the mitochondria....
The heart is highly sensitive to the aging process. In the elderly, the heart tends to become hypert...
Mitochondrial dynamics, including fission and fusion processes, are essential for heart health. Mito...
Autophagy is a major catabolic pathway by which mammalian cells degrade and recycle macromolecules a...
Autophagy is an evolutionarily conserved mechanism by which cytoplasmic elements are degraded intrac...
Artículo de publicación ISICardiac hypertrophy is often initiated as an adaptive response to haemody...
Artículo de publicación ISICardiac hypertrophy is often initiated as an adaptive response to haemody...
Cardiomyocytes are subjected to the intense mechanical stress and metabolic demands of the beating h...
Abstract Mitochondria are paramount to the metabolism and survival of cardiomyocytes. Here we show t...
International audienceMitochondria are paramount to the metabolism and survival of cardiomyocytes. H...