Specific tissue responses to thyroid hormone are mediated by the hormone binding to two subtypes of nuclear receptors, TRα and TRβ. We investigated the relationship between TRβ activation and liver oxidative metabolism in hypothyroid rats treated with equimolar doses of triiodothyronine (T3) and GC-1, a TRb agonist. T3 treatment produces increases in O2 consumption and H2O2 production higher than those elicited by GC-1. The greater effects of T 3 on oxidative processes are linked to the higher hormonal stimulation of the content of respiratory chain components including autoxidizable electron carriers as demonstrated by the measurement of activities of respiratory complexes and H2O2 generation in the presence of respiratory inhibitors. It i...
Growing evidence shows that, among triiodothyronine derivatives, 3,5 diiodo-L-thyronine (T2) plays a...
AbstractBesides triiodothyronine (T3), 3,5-diiodo-L-thyronine (T2) has been reported to affect mitoc...
AbstractWe investigated the mechanism by which 3,5-diiodo-l-thyronine (T2) affects skeletal muscle m...
J Endocrinol. 2010 Jun;205(3):279-89. Epub 2010 Apr 1. The TRbeta-selective agonist, GC-1, stimulat...
Specific tissue responses to thyroid hormone are mediated by the hormone binding to two subtypes of ...
J Exp Biol. 2009 Apr;212(Pt 7):986-93. T3 and the thyroid hormone beta-receptor agonist GC-1 differ...
We compared the changes in tissue aerobic metabolism and oxidative damage elicited by hypothyroid ra...
Background/Aims: Both 3,5-diiodo-L-thyronine (3,5-T2) and 3,5,3’-triiodo-L-tyronine (T3) affect ener...
Both 3,5-diiodo-L-thyronine (3,5-T2) and 3,5,3'-triiodo-L-tyronine (T3) affect energy metabolism hav...
BACKGROUND/AIMS: Both 3,5-diiodo-L-thyronine (3,5-T2) and 3,5,3'-triiodo-L-tyronine (T3) affect ene...
AbstractIn the present study the effect of thyroid hormone (T3) on oxidative stress parameters of mi...
The development of thyroid hormone (TH) analogues was prompted by the attempt to exploit the effects...
Thyroid hormone has a profound impact on mammalian metabolism; hypothyroidism causes decreased metab...
This study evaluated the effect of 3,5-diiodo-L-thyronine (T2) and 3,5,3′-triiodo-L-thyronine (T3) o...
This study evaluated the effect of 3,5-diiodo-L-thyronine (T2) and 3,5,3′-triiodo-L-thyronine (T3) o...
Growing evidence shows that, among triiodothyronine derivatives, 3,5 diiodo-L-thyronine (T2) plays a...
AbstractBesides triiodothyronine (T3), 3,5-diiodo-L-thyronine (T2) has been reported to affect mitoc...
AbstractWe investigated the mechanism by which 3,5-diiodo-l-thyronine (T2) affects skeletal muscle m...
J Endocrinol. 2010 Jun;205(3):279-89. Epub 2010 Apr 1. The TRbeta-selective agonist, GC-1, stimulat...
Specific tissue responses to thyroid hormone are mediated by the hormone binding to two subtypes of ...
J Exp Biol. 2009 Apr;212(Pt 7):986-93. T3 and the thyroid hormone beta-receptor agonist GC-1 differ...
We compared the changes in tissue aerobic metabolism and oxidative damage elicited by hypothyroid ra...
Background/Aims: Both 3,5-diiodo-L-thyronine (3,5-T2) and 3,5,3’-triiodo-L-tyronine (T3) affect ener...
Both 3,5-diiodo-L-thyronine (3,5-T2) and 3,5,3'-triiodo-L-tyronine (T3) affect energy metabolism hav...
BACKGROUND/AIMS: Both 3,5-diiodo-L-thyronine (3,5-T2) and 3,5,3'-triiodo-L-tyronine (T3) affect ene...
AbstractIn the present study the effect of thyroid hormone (T3) on oxidative stress parameters of mi...
The development of thyroid hormone (TH) analogues was prompted by the attempt to exploit the effects...
Thyroid hormone has a profound impact on mammalian metabolism; hypothyroidism causes decreased metab...
This study evaluated the effect of 3,5-diiodo-L-thyronine (T2) and 3,5,3′-triiodo-L-thyronine (T3) o...
This study evaluated the effect of 3,5-diiodo-L-thyronine (T2) and 3,5,3′-triiodo-L-thyronine (T3) o...
Growing evidence shows that, among triiodothyronine derivatives, 3,5 diiodo-L-thyronine (T2) plays a...
AbstractBesides triiodothyronine (T3), 3,5-diiodo-L-thyronine (T2) has been reported to affect mitoc...
AbstractWe investigated the mechanism by which 3,5-diiodo-l-thyronine (T2) affects skeletal muscle m...