Preparation and solid state properties of cyclodextrin complexes of selected drug molecules

Includes bibliographical references.A large number of pharmaceutically important drugs are poorly soluble in water. This study focuses on the 'smart' molecule that can enhance the solubility and hence increase the bioavailability of these drugs. This molecule is a cyclodextrin and is known to form inclusion compounds with various drug molecules. The preparation of β-cyclodextrin CP-CD), y-cyclodextrin (y-CD), heptakis(2,6-di-OJ, methyl)-β-cyclodextrin (Dimeb) and heptakis(2,3,6·tri-0-methyl)- β-cyclodextrin (Trimeb) 3, complexes with clofibric acid as well as the heptakis(2,3,6j·tri-O-methyl)- β-cyclodextrin (Trimeb) complex with clofibrate is reported. The complexes were characterised by thermogravimetric analysis (TG), differential scanning calorimetry (DSC), ultraviolet spectrophotometry (UV), infrared spectroscopy (IR), X-ray powder diffraction (XRD) and single crystal X-ray analysis