Adenosine deaminases acting on RNA (ADARs) catalyze the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) and thereby potentially alter the information content and structure of cellular RNAs. Notably, although the overwhelming majority of such editing events occur in transcripts derived from Alu repeat elements, the biological function of non-coding RNA editing remains uncertain. Here, we show that mutations in ADAR1 (also known as ADAR) cause the autoimmune disorder Aicardi-Goutières syndrome (AGS). As in Adar1-null mice, the human disease state is associated with upregulation of interferon-stimulated genes, indicating a possible role for ADAR1 as a suppressor of type I interferon signaling. Considering recent i...
Loss of function of adenosine deaminase acting on double-stranded RNA (dsRNA)-1 (ADAR1) causes the s...
Loss of function of adenosine deaminase acting on double-stranded RNA (dsRNA)-1 (ADAR1) causes the s...
Loss of function of adenosine deaminase acting on double-stranded RNA (dsRNA)-1 (ADAR1) causes the s...
Adenosine deaminases acting on RNA (ADARs) catalyze the hydrolytic deamination of adenosine to inosi...
Adenosine deaminases acting on RNA (ADARs) catalyze the hydrolytic deamination of adenosine to inosi...
Adenosine deaminases acting on RNA (ADARs) catalyze the hydrolytic deamination of adenosine to inosi...
Adenosine deaminases acting on RNA (ADARs) catalyze the hydrolytic deamination of adenosine to inosi...
Adenosine deaminases acting on RNA (ADARs) catalyze the hydrolytic deamination of adenosine to inosi...
Adenosine deaminases acting on RNA (ADARs) catalyze the hydrolytic deamination of adenosine to inosi...
Adenosine deaminases acting on RNA (ADARs) catalyze the hydrolytic deamination of adenosine to inosi...
Adenosine deaminases acting on RNA (ADARs) catalyze the hydrolytic deamination of adenosine to inosi...
Adenosine deaminases acting on RNA (ADARs) catalyze the hydrolytic deamination of adenosine to inosi...
Adenosine deaminases acting on RNA (ADARs) catalyze the hydrolytic deamination of adenosine to inosi...
Adenosine deaminases acting on RNA (ADARs) catalyze the hydrolytic deamination of adenosine to inosi...
Loss of function of adenosine deaminase acting on double-stranded RNA (dsRNA)-1 (ADAR1) causes the s...
Loss of function of adenosine deaminase acting on double-stranded RNA (dsRNA)-1 (ADAR1) causes the s...
Loss of function of adenosine deaminase acting on double-stranded RNA (dsRNA)-1 (ADAR1) causes the s...
Loss of function of adenosine deaminase acting on double-stranded RNA (dsRNA)-1 (ADAR1) causes the s...
Adenosine deaminases acting on RNA (ADARs) catalyze the hydrolytic deamination of adenosine to inosi...
Adenosine deaminases acting on RNA (ADARs) catalyze the hydrolytic deamination of adenosine to inosi...
Adenosine deaminases acting on RNA (ADARs) catalyze the hydrolytic deamination of adenosine to inosi...
Adenosine deaminases acting on RNA (ADARs) catalyze the hydrolytic deamination of adenosine to inosi...
Adenosine deaminases acting on RNA (ADARs) catalyze the hydrolytic deamination of adenosine to inosi...
Adenosine deaminases acting on RNA (ADARs) catalyze the hydrolytic deamination of adenosine to inosi...
Adenosine deaminases acting on RNA (ADARs) catalyze the hydrolytic deamination of adenosine to inosi...
Adenosine deaminases acting on RNA (ADARs) catalyze the hydrolytic deamination of adenosine to inosi...
Adenosine deaminases acting on RNA (ADARs) catalyze the hydrolytic deamination of adenosine to inosi...
Adenosine deaminases acting on RNA (ADARs) catalyze the hydrolytic deamination of adenosine to inosi...
Adenosine deaminases acting on RNA (ADARs) catalyze the hydrolytic deamination of adenosine to inosi...
Loss of function of adenosine deaminase acting on double-stranded RNA (dsRNA)-1 (ADAR1) causes the s...
Loss of function of adenosine deaminase acting on double-stranded RNA (dsRNA)-1 (ADAR1) causes the s...
Loss of function of adenosine deaminase acting on double-stranded RNA (dsRNA)-1 (ADAR1) causes the s...
Loss of function of adenosine deaminase acting on double-stranded RNA (dsRNA)-1 (ADAR1) causes the s...