Recent years have seen an increasing interest in the philosophy of disagreement, especially in epistemology where there is an intense debate over the epistemic significance of disagreement and higher-order evidence more generally. Considerations about disagreement also play an important role in metaethics – most prominently in various arguments that purport to establish moral skepticism. This thesis presents five papers that address moral disagreement and the significance of higher-order evidence. The first two papers develop a view about higher-order defeat that is used in the dissertation. The other three papers consider specific arguments from disagreement. The third paper argues that the Argument from Peer Disagreement fails to make a c...