Poly(hydroxyalkanoate) monomers as source for biological active compounds synthesis

Sintetisali smo biblioteku od 18 derivata (R)-3-hidroksioktanske kiseline,monomera bakterijskog polimera poli(hidroksialkanoata). Sva jedinjenja suokarakterisana i testirana je njihova antimikrobna i antiproliferativna aktivnost. Kakobismo ispitali značaj konfiguracije na hiralnom centru polazne kiseline za njenubiološku aktivnost, sintetisan je (S)-metil-3-hidroksioktanoat. U okviru teze je ispitanamogućnost konjugacije 3-hidroksialkanskih kiselina različite dužine lanca i hemijskisintetisane 3-hlordekanske kiseline na antikancerski peptid kao i uticaj na promenubiološke aktivnosti peptida.We have synthesized a library of 18 derivatives from (R)-3-hydroxyoctanoicacid, monomer of bacterial polymer poly(hydroxyalkanoate). All compounds werecharacterized and tested for their antimicrobial and anti-proliferative activity. In order toexamine the significance of the configuration of the chiral center of the starting acid inthe biological activity, (S)-methyl-3-hydroxyalkanoate was synthesized. Within the PhDthesis the possibility of conjugation 3-hydroxy alkanoic acids of different chain lengthand chemically synthesized 3-chloro octanoic acid with anticancer peptide wasinvestigated, and impact of conjugation in changing biological activity of the peptide