Study of the cytotoxic activity of alkenyl-substituted ansa-titanocene complexes

The cytotoxic activity on tumour cell lines, human adenocarcinoma HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x and normal immunocompetent cells, was tested for four different ansa-titanocene dichloride derivatives with potentially reactive substituents [Ti{Me{(CH2=CH)Si(eta(5)-Me-5(4)) (eta(5)-C5H4))Cl-2] (1), [Ti{Me(H)Si(eta(5)-C5Me4)(2)}Cl-2] (2), [Ti{Me{(CH2=CH)Me2SiCH2CH2}Si(eta(5)-C5Me4)(eta(5)-C5H4)}Cl-2] (3) and [Ti{Me2Si(eta(5)-C5Me4)(eta(5)-C5H3(CMe2(CH2CH2CH=CH2)))}Cl-2] (4), showing a very promising activity and opening up the possibility of extensive investigation in this field. (c) 2007 Elsevier B.V. All rights reserved