THE EXTRACT Glycine max (L.) Merr. OF DETAM II VARIETY ON LEAD LEVEL AND KIDNEY'S HISTOPATHOLOGY IN MICE WITH LEAD INTOXICATION

Lead intoxication into the body to produce free radical compounds. Kidney is one of the excretory organs that are susceptible to free radical attack. Detam II variety of soybean is a type of superior soybean varieties in Indonesia containing isoflavones, allegedly useful to reduce the accumulation of lead in the body and protect the kidneys. The aim this study was determined the effect extract soyabean of Detam II variety obtained by maceration kinetic using 90% methanol solvent on kidney's histopathology and lead level in mice blood The study was randomized pretest post test control group design. Animals model were 30 mice divided into 6 groups, placebo, negative control (lead only), positive control (soybean extract only), test group (soybean Detam II variety) and gold standard group (lead + Vit C). All groups were exposed with acetate lead at a dose of25 mg/kg BW/day except the placebo group and positive controls. The process of intoxication was continued by giving Detam II variety of soybean extract at doses of 75 mg/kg BW in positive control group and test group. In the gold standard group was given vitamin C dose of 64 mg/kg BW/day and aquadem in the placebo group for seven days. The results were appreciated by extract Glycine max (L.) Merr. of Detam II variety on blood lead levels and effectively to repair kidney's histopathology. Conclusion: Extract Glycine max L. Merr. of Detam II variety has lowering lead levels in blood and effectively to repair kidney's histopathology