The complete genome sequence of the gram-positive bacterium Bacillus subtilis.
- Kunst, F.
- Ogasawara, N.
- Moszer, I.
- Albertini, A.M.
- Alloni, G.
- Azevedo, V.
- Bertero, M.G.
- Bessières, P.
- Bolotin, A.
- Borchert, S.
- Borriss, R.
- Boursier, L.
- Brans, A.
- Braun, M.
- Brignell, S.C.
- Bron, S.
- Brouillet, S.
- Bruschi, C.V.
- Caldwell, B.
- Capuano, V.
- Carter, N.M.
- Choi, S.K.
- Codani, J.J.
- Connerton, I.F.
- Cummings, N.J.
- Daniel, R.A.
- Denizot, F.
- Devine, K.M.
- Dusterhoft, A.
- Ehrlich, S.D.
- Emmerson, P.T.
- Entian, K.D.
- Errington, J.
- Fabret, C.
- Ferrari, E.
- Foulger, D.
- Fritz, C.
- Fujita, M.
- Fujita, Y.
- Fuma, S.
- Galizzi, A.
- Galleron, N.
- Ghim, S.Y.
- Glaser, P.
- Goffeau, A.
- Golightly, E.J.
- Grandi, G.
- Guiseppi, G.
- Guy, B.J.
- Haga, K.
- Haiech, J.
- Harwood, C.R.
- Hénaut, A.
- Hilbert, H.
- Holsappel, S.
- Hosono, S.
- Hullo, M.F.
- Itaya, M.
- Jones, L.
- Joris, B.
- Karamata, D.
- Kasahara, Y.
- Klaerr-Blanchard, M.
- Klein, C.
- Kobayashi, Y.
- Koetter, P.
- Koningstein, G.
- Krogh, S.
- Kumano, M.
- Kurita, K.
- Lapidus, A.
- Lardinois, S.
- Lauber, J.
- Lazarevic, V.
- Lee, S.M.
- Levine, A.
- Liu, H.
- Masuda, S.
- Mauël, C.
- Médigue, C.
- Medina, N.
- Mellado, R.P.
- Mizuno, M.
- Moestl, D.
- Nakai, S.
- Noback, M.
- Noone, D.
- O'Reilly, M.O.
- Ogawa, K.
- Ogiwara, A.
- Oudega, B.
- Park, S.H.
- Parro, V.
- Pohl, T.M.
- Portetelle, D.
- Porwollik, S.
- Prescott, A.M.
- Presecan, E.
- Pujic, P.
- Purnelle, B.
- Rapoport, G.
- Rey, M.
- Reynolds, S.
- Rieger, M.
- Rivolta, C.
- Rocha, E.
- Roche, B.
- Rose, M.
- Sadaie, Y.
- Sato, T.
- Scanlan, E.
- Schleich, S.
- Schroeter, R.
- Scoffone, F.
- Sekiguchi, J.
- Sekowska, A.
- Seror, S.J.
- Serror, P.
- Shin, B.S.
- Soldo, B.
- Sorokin, A.
- Tacconi, E.
- Takagi, T.
- Takahashi, H.
- Takemaru, K.
- Takeuchi, M.
- Tamakoshi, A.
- Tanaka, T.
- Terpstra, P.
- Tognoni, A.
- Tosato, V.
- Uchiyama, S.
- Vandenbol, M.
- Vannier, F.
- Vassarotti, A.
- Viari, A.
- Wambutt, R.
- Wedler, E.
- Wedler, H.
- Weitzenegger, T.
- Winters, P.
- Wipat, A.
- Yamamoto, H.
- Yamane, K.
- Yasumoto, K.
- Yata, K.
- Yoshida, K.
- Yoshikawa, H.F.
- Zumstein, E.
- Yoshikawa, H.
- Danchin, A.
DOIAbstract
Bacillus subtilis is the best-characterized member of the Gram-positive bacteria. Its genome of 4,214,810 base pairs comprises 4,100 protein-coding genes. Of these protein-coding genes, 53% are represented once, while a quarter of the genome corresponds to several gene families that have been greatly expanded by gene duplication, the largest family containing 77 putative ATP-binding transport proteins. In addition, a large proportion of the genetic capacity is devoted to the utilization of a variety of carbon sources, including many plant-derived molecules. The identification of five signal peptidase genes, as well as several genes for components of the secretion apparatus, is important given the capacity of Bacillus strains to secrete larg...
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