Antigen receptor-induced NF-kappaB activation depends on receptor-proximal and -distal signaling events. Two papers in this issue of Immunity demonstrate that PKC-dependent phosphorylation of CARMA1 is the critical molecular link that controls the activation of the IKK signalosome and NF-kappaB
CARMA proteins are scaffold molecules that contain a caspase recruitment domain and a membrane-assoc...
The transcription factor NF-kB plays a key regulatory role in lymphocyte activation and generation o...
Bcl10, a caspase recruitment domain (CARD)-containing protein identified from a breakpoint in mucosa...
Antigen receptor-induced NF-κB activation depends on receptor-proximal and -distal signaling events....
SummaryPKC isoforms and CARMA1 play crucial roles in immunoreceptor-dependent NF-κB activation. We t...
SummaryCARMA1 mediates T cell receptor (TCR)-induced NF-κB activation. However, how TCR links to CAR...
AbstractLymphocyte activation via antigen receptors initiates adaptive immune responses. Two papers ...
Activation of the NF-kappaB pathway in T cells is required for induction of an adaptive immune respo...
CARMA proteins are scaffold molecules that contain a caspase recruitment domain and a membrane-assoc...
The Carma1-Bcl10-Malt1 (CBM) complex bridges T-cell receptor (TCR) signalling to the canonical I&kap...
Activation of the transcription factor NF-kB after engagement of the T cell receptor (TCR) is import...
CARMA1 is a lymphocyte-specific member of the membrane-associated guanylate kinase (MAGUK) family of...
T cells are critical players in adaptive immunity. They migrate throughout the body scanning the ly...
Antigen recognition by the T cell receptor (TCR) elicits several intracellular signaling cascades, o...
Ligation of antigen receptors (TCR, BCR) on T and B lymphocytes leads to the activation of new trans...
CARMA proteins are scaffold molecules that contain a caspase recruitment domain and a membrane-assoc...
The transcription factor NF-kB plays a key regulatory role in lymphocyte activation and generation o...
Bcl10, a caspase recruitment domain (CARD)-containing protein identified from a breakpoint in mucosa...
Antigen receptor-induced NF-κB activation depends on receptor-proximal and -distal signaling events....
SummaryPKC isoforms and CARMA1 play crucial roles in immunoreceptor-dependent NF-κB activation. We t...
SummaryCARMA1 mediates T cell receptor (TCR)-induced NF-κB activation. However, how TCR links to CAR...
AbstractLymphocyte activation via antigen receptors initiates adaptive immune responses. Two papers ...
Activation of the NF-kappaB pathway in T cells is required for induction of an adaptive immune respo...
CARMA proteins are scaffold molecules that contain a caspase recruitment domain and a membrane-assoc...
The Carma1-Bcl10-Malt1 (CBM) complex bridges T-cell receptor (TCR) signalling to the canonical I&kap...
Activation of the transcription factor NF-kB after engagement of the T cell receptor (TCR) is import...
CARMA1 is a lymphocyte-specific member of the membrane-associated guanylate kinase (MAGUK) family of...
T cells are critical players in adaptive immunity. They migrate throughout the body scanning the ly...
Antigen recognition by the T cell receptor (TCR) elicits several intracellular signaling cascades, o...
Ligation of antigen receptors (TCR, BCR) on T and B lymphocytes leads to the activation of new trans...
CARMA proteins are scaffold molecules that contain a caspase recruitment domain and a membrane-assoc...
The transcription factor NF-kB plays a key regulatory role in lymphocyte activation and generation o...
Bcl10, a caspase recruitment domain (CARD)-containing protein identified from a breakpoint in mucosa...
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