OBJECTIVES: HLA-B*5701 is a major histocompatibility complex class I allele associated with an immunologically-mediated hypersensitivity reaction to abacavir. The objectives of this study were to evaluate HLA-B*5701 prevalence among European, HIV-1-infected patients and to compare the local and central laboratory screening results. METHODS: Data were combined from six multicentre, prospective studies involving 10 European countries in which HIV-1-infected patients (irrespective of treatment experience or previous HLA-B*5701 screening), >or=18 years of age, were evaluated for HLA-B*5701 carriage, determined by the central and local laboratory methods. RESULTS: A total of 9720 patients from 272 centres were included in the analysis. The ov...
BACKGROUND: The presence of the HLA-B*57:01 allele in HIV-infected subjects is associated with a hig...
The introduction of highly active antiretroviral therapy (also known as combination therapy) has tra...
Abacavir is a nucleoside reverse transcriptase inhibitor used as part of combination antiretroviral ...
Background: Abacavir is an anti-retroviral medication used to treat HIV infected/AIDS patients and i...
Objectives: HLA-B*5701 strongly predicts abacavir hypersensitivity (HSR), but implementation of effe...
Abstract Background The presence of the HLA-B*57:01 allele in HIV-infected subjects is associated wi...
International audienceBackground: The presence of the human leukocyte antigen HLA-B*57:01 is associa...
Abacavir is a nucleoside reverse transcriptase inhibitor largely used as part of the antiretroviral ...
This study was designed to establish the prevalence of HLA-B*5701 at HIV-1 infected individuals in B...
OBJECTIVES: To determine the frequencies of HLA-B alleles in Ugandan patients in the NORA substudy o...
Objectives: To describe the incidence of hypersensitivity to abacavir and frequency of human leucocy...
It has been demonstrated that HLA-B*5701 screening reduces the risk for hypersensitivity reaction to...
The HLA-B*57:01 allele is strongly associated with the hypersensitivity reaction to Abacavir (ABC). ...
Objective: Retrospective analyses have identified several risk factors for abacavir (ABC) HSR, howev...
Objectives To determine the frequencies of HLA-B alleles in Ugandan patients in the NORA substudy of...
BACKGROUND: The presence of the HLA-B*57:01 allele in HIV-infected subjects is associated with a hig...
The introduction of highly active antiretroviral therapy (also known as combination therapy) has tra...
Abacavir is a nucleoside reverse transcriptase inhibitor used as part of combination antiretroviral ...
Background: Abacavir is an anti-retroviral medication used to treat HIV infected/AIDS patients and i...
Objectives: HLA-B*5701 strongly predicts abacavir hypersensitivity (HSR), but implementation of effe...
Abstract Background The presence of the HLA-B*57:01 allele in HIV-infected subjects is associated wi...
International audienceBackground: The presence of the human leukocyte antigen HLA-B*57:01 is associa...
Abacavir is a nucleoside reverse transcriptase inhibitor largely used as part of the antiretroviral ...
This study was designed to establish the prevalence of HLA-B*5701 at HIV-1 infected individuals in B...
OBJECTIVES: To determine the frequencies of HLA-B alleles in Ugandan patients in the NORA substudy o...
Objectives: To describe the incidence of hypersensitivity to abacavir and frequency of human leucocy...
It has been demonstrated that HLA-B*5701 screening reduces the risk for hypersensitivity reaction to...
The HLA-B*57:01 allele is strongly associated with the hypersensitivity reaction to Abacavir (ABC). ...
Objective: Retrospective analyses have identified several risk factors for abacavir (ABC) HSR, howev...
Objectives To determine the frequencies of HLA-B alleles in Ugandan patients in the NORA substudy of...
BACKGROUND: The presence of the HLA-B*57:01 allele in HIV-infected subjects is associated with a hig...
The introduction of highly active antiretroviral therapy (also known as combination therapy) has tra...
Abacavir is a nucleoside reverse transcriptase inhibitor used as part of combination antiretroviral ...